Small molecule targeting miR-34a for cancer therapy #MMPMID27308410
Xiao Z; Chen Y
Mol Cell Oncol 2015[Jan]; 2 (1): ä PMID27308410show ga
miR-34a functions as a tumor suppressor in many cancers. In a recent issue of Cancer Research, we describe a small molecule, Rubone, with strong anticancer activity. Rubone selectively restored miR-34a expression in hepatocellular carcinoma cells in which miR-34a was silenced. Restoration of miR-34a by Rubone represents a promising therapeutic approach against cancer.