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10.4161/mco.29911 http://scihub22266oqcxt.onion/10.4161/mco.29911 C4905171!4905171!27308318     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Mol+Cell+Oncol 2014 ; 1 (1): ä Nephropedia Template TP {{tp|p=27308318|t=2014. Chloroquine and hydroxychloroquine for cancer therapy |pdf=|usr=}}{{27308318}} gab.com Text Chloroquine and hydroxychloroquine for cancer therapy JO: Mol Cell Oncol http://www.kidney.de/pget.php?&tw=1&pmid=27308318 #FOAvip Macroautophagy (herein referred to as autophagy) is a highly conserved mechanism for the lysosomal degradation of cytoplasmic components. Autophagy is critical for the maintenance of intracellular homeostasis, both in baseline conditions and in the context of adaptive responses to stress. In line with this notion, defects in the autophagic machinery have been etiologically associated with various human disorders including infectious, inflammatory and neoplastic conditions. Once tumors are established, however, autophagy sustains the survival of malignant cells, hence representing an appealing target for the design of novel anticancer regimens. Accordingly, inhibitors of autophagy including chloroquine and hydroxychloroquine have been shown to mediate substantial antineoplastic effects in preclinical models, especially when combined with chemo- or radiotherapeutic interventions. The pharmacological profile of chloroquine and hydroxychloroquine, however, appear to involve mechanisms other than autophagy inhibition. Here, we discuss the dual role of autophagy in oncogenesis and tumor progression, and summarize the results or design of clinical studies recently completed or initiated to evaluate the therapeutic activity of chloroquine derivatives in cancer patients. Twit Text FOAVip Chloroquine and hydroxychloroquine for cancer therapy ????Mol Cell Oncol http://www.kidney.de/pget.php?&tw=1&pmid=27308318 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27308318 #FOAvip English Wikipedia <ref>{{Cite pmid|27308318}}</ref> Chloroquine and hydroxychloroquine for cancer therapy #MMPMID27308318 Manic G; Obrist F; Kroemer G; Vitale I; Galluzzi L Mol Cell Oncol 2014[]; 1 (1): ä PMID27308318show ga Macroautophagy (herein referred to as autophagy) is a highly conserved mechanism for the lysosomal degradation of cytoplasmic components. Autophagy is critical for the maintenance of intracellular homeostasis, both in baseline conditions and in the context of adaptive responses to stress. In line with this notion, defects in the autophagic machinery have been etiologically associated with various human disorders including infectious, inflammatory and neoplastic conditions. Once tumors are established, however, autophagy sustains the survival of malignant cells, hence representing an appealing target for the design of novel anticancer regimens. Accordingly, inhibitors of autophagy including chloroquine and hydroxychloroquine have been shown to mediate substantial antineoplastic effects in preclinical models, especially when combined with chemo- or radiotherapeutic interventions. The pharmacological profile of chloroquine and hydroxychloroquine, however, appear to involve mechanisms other than autophagy inhibition. Here, we discuss the dual role of autophagy in oncogenesis and tumor progression, and summarize the results or design of clinical studies recently completed or initiated to evaluate the therapeutic activity of chloroquine derivatives in cancer patients. äChloroquine and hydroxychloroquine for cancer therapy (epmc).pdf DeepDyve Pubget Overpricing