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10.4161/23723548.2014.965631

http://scihub22266oqcxt.onion/10.4161/23723548.2014.965631
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C4904990!4904990!27308414
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suck abstract from ncbi


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pmid27308414      Mol+Cell+Oncol 2015 ; 2 (2): ä
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  • Do changes in the c-MYC coding sequence contribute to tumorigenesis? #MMPMID27308414
  • Chakraborty AA; Tansey WP
  • Mol Cell Oncol 2015[Apr]; 2 (2): ä PMID27308414show ga
  • The role of changes in the c-MYC coding sequence in cancer is controversial. Overexpression of wild-type protein is sufficient to drive tumorigenesis, yet point mutations in c-MYC are common in Burkitt's lymphoma. Our discovery that disparate tumor-associated mutations in c-MYC have similar protumorigenic effects suggests that these mutations contribute directly to malignancy.
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