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10.4161/23723548.2014.963447 http://scihub22266oqcxt.onion/10.4161/23723548.2014.963447 C4904898!4904898!27308344     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Mol+Cell+Oncol 2014 ; 1 (3): ä Nephropedia Template TP {{tp|p=27308344|t=2014. Rationale-based therapeutic combinations with PI3K inhibitors in cancer treatment |pdf=|usr=}}{{27308344}} gab.com Text Rationale-based therapeutic combinations with PI3K inhibitors in cancer treatment JO: Mol Cell Oncol http://www.kidney.de/pget.php?&tw=1&pmid=27308344 #FOAvip The PI3K/AKT/mTOR signaling is important for cell proliferation, survival, and metabolism. Hyperactivation of this pathway is one of the most common signaling abnormalities observed in cancer and a substantial effort has recently been made to develop molecules targeting this signaling cascade. However, it is becoming evident that PI3K inhibitors used as single agents do not elicit dramatic or durable responses. Given the numerous mechanisms mediating intrinsic and acquired resistance to these agents, hypothesis-based combinatorial strategies are probably needed to fully exploit their antitumor activity. In the first part of this review, we briefly dissect the PI3K/AKT/mTOR axis and list the most advanced compounds targeting different nodes of this cascade. The second part focuses on what we believe to be the most promising rationale-based therapeutic combinations with PI3K/AKT/mTOR inhibitors in solid tumors, with special emphasis on breast cancer. Twit Text FOAVip Rationale-based therapeutic combinations with PI3K inhibitors in cancer treatment ????Mol Cell Oncol http://www.kidney.de/pget.php?&tw=1&pmid=27308344 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27308344 #FOAvip English Wikipedia <ref>{{Cite pmid|27308344}}</ref> Rationale-based therapeutic combinations with PI3K inhibitors in cancer treatment #MMPMID27308344 Castel P; Toska E; Zumsteg ZS; Carmona FJ; Elkabets M; Bosch A; Scaltriti M Mol Cell Oncol 2014[Jul]; 1 (3): ä PMID27308344show ga The PI3K/AKT/mTOR signaling is important for cell proliferation, survival, and metabolism. Hyperactivation of this pathway is one of the most common signaling abnormalities observed in cancer and a substantial effort has recently been made to develop molecules targeting this signaling cascade. However, it is becoming evident that PI3K inhibitors used as single agents do not elicit dramatic or durable responses. Given the numerous mechanisms mediating intrinsic and acquired resistance to these agents, hypothesis-based combinatorial strategies are probably needed to fully exploit their antitumor activity. In the first part of this review, we briefly dissect the PI3K/AKT/mTOR axis and list the most advanced compounds targeting different nodes of this cascade. The second part focuses on what we believe to be the most promising rationale-based therapeutic combinations with PI3K/AKT/mTOR inhibitors in solid tumors, with special emphasis on breast cancer. äRationale-based therapeutic combinations with PI3K inhibitors in cance(epmc).pdf DeepDyve Pubget Overpricing