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2014 ; 1
(3
): e964024
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gab.com Text
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English Wikipedia
VEGF signaling, mTOR complexes, and the endoplasmic reticulum: Towards a role of
metabolic sensing in the regulation of angiogenesis
#MMPMID27308350
Karali E
; Bellou S
; Stellas D
; Klinakis A
; Murphy C
; Fotsis T
Mol Cell Oncol
2014[Jul]; 1
(3
): e964024
PMID27308350
show ga
Vascular endothelial growth factor (VEGF) activates unfolded protein response
sensors in the endoplasmic reticulum through phospholipase C gamma
(PLC?)-mediated crosstalk with mammalian target of rapamycin complex 1 (mTORC1).
Activation of transcription factor 6 (ATF6) and protein kinase RNA-like
endoplasmic reticulum kinase (PERK) activate mTORC2, ensuring maximal endothelial
cell survival and angiogenic activity through phosphorylation of AKT on Ser473.
As mTORC1 is a metabolic sensor, metabolic signals may be integrated with signals
from VEGF in the regulation of angiogenesis.