TRIM32 is a novel negative regulator of p53 #MMPMID27308422
Liu J; Zhu Y; Hu W; Feng Z
Mol Cell Oncol 2015[Apr]; 2 (2): ä PMID27308422show ga
To ensure proper function, the tumor suppressor p53 is tightly regulated through different post-translational modifications, particularly ubiquitination. Recently, TRIM32 was identified as a p53-regulated gene and an E3 ubiquitin ligase of p53. Thus, TRIM32 and p53 form a novel auto-regulatory negative feedback loop for p53 regulation in cells.