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10.4161/23723556.2014.975641 http://scihub22266oqcxt.onion/10.4161/23723556.2014.975641 C4904880!4904880!27308435     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=27308435&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Mol+Cell+Oncol 2015 ; 2 (2): ä Nephropedia Template TP {{tp|p=27308435|t=2015. A new ?angle? on kinase inhibitor design: Prioritizing amphosteric activity above kinase inhibition |pdf=|usr=}}{{27308435}} gab.com Text A new angle on kinase inhibitor design: Prioritizing amphosteric activity above kinase inhibition JO: Mol Cell Oncol http://www.kidney.de/pget.php?&tw=1&pmid=27308435 #FOAvip The MYCN oncoprotein has remained an elusive target for decades. We recently reported a new class of kinase inhibitors designed to disrupt the conformation of Aurora kinase A enough to block its kinase-independent interaction with MYCN, resulting in potent degradation of MYCN. These studies provide proof-of-principle for a new method of targeting enzyme activity-independent functions of kinases and other enzymes. Twit Text FOAVip A new angle on kinase inhibitor design: Prioritizing amphosteric activity above kinase inhibition ????Mol Cell Oncol http://www.kidney.de/pget.php?&tw=1&pmid=27308435 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27308435 #FOAvip English Wikipedia <ref>{{Cite pmid|27308435}}</ref> A new ?angle? on kinase inhibitor design: Prioritizing amphosteric activity above kinase inhibition #MMPMID27308435 Meyerowitz JG; Weiss WA; Gustafson WC Mol Cell Oncol 2015[Apr]; 2 (2): ä PMID27308435show ga The MYCN oncoprotein has remained an elusive target for decades. We recently reported a new class of kinase inhibitors designed to disrupt the conformation of Aurora kinase A enough to block its kinase-independent interaction with MYCN, resulting in potent degradation of MYCN. These studies provide proof-of-principle for a new method of targeting enzyme activity-independent functions of kinases and other enzymes. äA new ?angle? on kinase inhibitor design: Prioritizing amphosteric act(epmc).pdf DeepDyve Pubget Overpricing