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10.3109/10641955.2015.1032054

http://scihub22266oqcxt.onion/10.3109/10641955.2015.1032054
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suck abstract from ncbi


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pmid25996051
      Hypertens+Pregnancy 2015 ; 34 (3 ): 291-306
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  • IL-10 supplementation increases Tregs and decreases hypertension in the RUPP rat model of preeclampsia #MMPMID25996051
  • Harmon A ; Cornelius D ; Amaral L ; Paige A ; Herse F ; Ibrahim T ; Wallukat G ; Faulkner J ; Moseley J ; Dechend R ; LaMarca B
  • Hypertens Pregnancy 2015[]; 34 (3 ): 291-306 PMID25996051 show ga
  • OBJECTIVE: The reduced uterine perfusion pressure (RUPP) rat model of preeclampsia was used to determine the effects of added interleukin-10 (IL-10) on Tregs and hypertension in response to placental ischemia and how the decrease in these anti-inflammatory factors mediates the pathophysiology of preeclampsia. METHODS: IL-10 (2.5?ng/kg/d) was infused via osmotic mini-pump implanted intraperitoneally on day 14 of gestation and, at the same time, the RUPP procedure was performed. RESULTS: IL-10 reduced mean arterial pressure (p?
  • |Animals [MESH]
  • |Blood Pressure/drug effects [MESH]
  • |Disease Models, Animal [MESH]
  • |Female [MESH]
  • |Hypertension/blood/*drug therapy/physiopathology [MESH]
  • |Interleukin-10/*pharmacology/therapeutic use [MESH]
  • |Interleukin-6/blood [MESH]
  • |Ischemia/drug therapy/metabolism [MESH]
  • |Placenta/blood supply/metabolism [MESH]
  • |Pre-Eclampsia/blood/*drug therapy/physiopathology [MESH]
  • |Pregnancy [MESH]
  • |Rats, Sprague-Dawley [MESH]
  • |T-Lymphocytes, Regulatory/*drug effects [MESH]


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