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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Hypertens+Pregnancy
2015 ; 34
(3
): 291-306
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IL-10 supplementation increases Tregs and decreases hypertension in the RUPP rat
model of preeclampsia
#MMPMID25996051
Harmon A
; Cornelius D
; Amaral L
; Paige A
; Herse F
; Ibrahim T
; Wallukat G
; Faulkner J
; Moseley J
; Dechend R
; LaMarca B
Hypertens Pregnancy
2015[]; 34
(3
): 291-306
PMID25996051
show ga
OBJECTIVE: The reduced uterine perfusion pressure (RUPP) rat model of
preeclampsia was used to determine the effects of added interleukin-10 (IL-10) on
Tregs and hypertension in response to placental ischemia and how the decrease in
these anti-inflammatory factors mediates the pathophysiology of preeclampsia.
METHODS: IL-10 (2.5?ng/kg/d) was infused via osmotic mini-pump implanted
intraperitoneally on day 14 of gestation and, at the same time, the RUPP
procedure was performed. RESULTS: IL-10 reduced mean arterial pressure
(p?0.001), decreased CD4(+) T cells (p?=?0.044), while increasing Tregs
(p?=?0.043) which led to lower IL-6 and TNF-? (p?=?0.008 and p?=?0.003), reduced
AT1-AA production (p?0.001), and decreased oxidative stress (p?=?0.029) in RUPP
rats. CONCLUSION: These data indicate that IL-10 supplementation increases Tregs
and helps to balance the altered immune system seen during preeclampsia.