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2016 ; 2016
(ä): 3585860
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Antineutrophil Cytoplasmic Antibody Induction due to Infection: A Patient with
Infective Endocarditis and Chronic Hepatitis C
#MMPMID27366166
Kamar FB
; Hawkins TL
Can J Infect Dis Med Microbiol
2016[]; 2016
(ä): 3585860
PMID27366166
show ga
While antineutrophil cytoplasmic antibody (ANCA) is often used as a diagnostic
marker for certain vasculitides, ANCA induction in the setting of infection is
much less common. In the case of infective endocarditis, patients may present
with multisystem disturbances resembling an autoimmune process, cases that may be
rendered even trickier to diagnose in the face of a positive ANCA. Though not
always straightforward, distinguishing an infective from an inflammatory process
is pivotal in order to guide appropriate therapy. We describe an encounter with a
43-year-old male with chronically untreated hepatitis C virus infection who
featured ANCA positivity while hospitalized with acute bacterial endocarditis.
His case serves as a reminder of two of the few infections known to uncommonly
generate ANCA positivity. We also summarize previously reported cases of ANCA
positivity in the context of endocarditis and hepatitis C infections.