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2016 ; 6
(ä): 28003
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Investigation of the cellular reprogramming phenomenon referred to as
stimulus-triggered acquisition of pluripotency (STAP)
#MMPMID27292224
Niwa H
Sci Rep
2016[Jun]; 6
(ä): 28003
PMID27292224
show ga
In January 2014, it was reported that strong external stimuli, such as a
transient low-pH stressor, was capable of inducing the reprogramming of mammalian
somatic cells, resulting in the generation of pluripotent cells. This cellular
reprograming event was designated 'stimulus-triggered acquisition of
pluripotency' (STAP) by the authors of these reports. However, after multiple
instances of scientific misconduct in the handling and presentation of the data
were brought to light, both reports were retracted. To investigate the actual
scientific significance of the purported STAP phenomenon, we sought to repeat the
original experiments based on the methods presented in the retracted manuscripts
and other relevant information. As a result, we have concluded that the STAP
phenomenon as described in the original studies is not reproducible.