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10.1186/s13008-016-0022-5 http://scihub22266oqcxt.onion/10.1186/s13008-016-0022-5 C4902950!4902950!27293474     free     free     free       Cell+Div 2016 ; 11 (ä): ä Nephropedia Template TP {{tp|p=27293474|t=2016. Cullin-RING ligases in regulation of autophagy |pdf=|usr=}}{{27293474}} gab.com Text Cullin-RING ligases in regulation of autophagy JO: Cell Div http://www.kidney.de/pget.php?&tw=1&pmid=27293474 #FOAvip Cullin-RING ligases (CRLs), the largest E3 ubiquitin ligase family, promote ubiquitination and degradation of various cellular key regulators involved in a broad array of physiological and pathological processes, including cell cycle progression, signal transduction, transcription, cardiomyopathy, and tumorigenesis. Autophagy, an intracellular catabolic reaction that delivers cytoplasmic components to lysosomes for degradation, is crucial for cellular metabolism and homeostasis. The dysfunction of autophagy has been proved to associate with a variety of human diseases. Recent evidences revealed the emerging roles of CRLs in the regulation of autophagy. In this review, we will focus mainly on recent advances in our understandings of the regulation of autophagy by CRLs and the cross-talk between CRLs and autophagy, two degradation systems. We will also discuss the pathogenesis of human diseases associated with the dysregulation of CRLs and autophagy. Finally, we will discuss current efforts and future perspectives on basic and translational research on CRLs and autophagy. Twit Text FOAVip Cullin-RING ligases in regulation of autophagy ????Cell Div http://www.kidney.de/pget.php?&tw=1&pmid=27293474 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27293474 #FOAvip English Wikipedia <ref>{{Cite pmid|27293474}}</ref> Cullin-RING ligases in regulation of autophagy #MMPMID27293474 Cui D; Xiong X; Zhao Y Cell Div 2016[]; 11 (ä): ä PMID27293474show ga Cullin-RING ligases (CRLs), the largest E3 ubiquitin ligase family, promote ubiquitination and degradation of various cellular key regulators involved in a broad array of physiological and pathological processes, including cell cycle progression, signal transduction, transcription, cardiomyopathy, and tumorigenesis. Autophagy, an intracellular catabolic reaction that delivers cytoplasmic components to lysosomes for degradation, is crucial for cellular metabolism and homeostasis. The dysfunction of autophagy has been proved to associate with a variety of human diseases. Recent evidences revealed the emerging roles of CRLs in the regulation of autophagy. In this review, we will focus mainly on recent advances in our understandings of the regulation of autophagy by CRLs and the cross-talk between CRLs and autophagy, two degradation systems. We will also discuss the pathogenesis of human diseases associated with the dysregulation of CRLs and autophagy. Finally, we will discuss current efforts and future perspectives on basic and translational research on CRLs and autophagy. äCullin-RING ligases in regulation of autophagy (epmc).pdf DeepDyve Pubget Overpricing