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10.1016/j.canlet.2015.12.003 http://scihub22266oqcxt.onion/10.1016/j.canlet.2015.12.003 C4902790!4902790 !26688098     free     free     free Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 249.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 249.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26688098 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Cancer+Lett 2016 ; 380 (1 ): 319-29 Nephropedia Template TP {{tp|p=26688098 |t=2016. Recapitulation of complex transport and action of drugs at the tumor microenvironment using tumor-microenvironment-on-chip |pdf=|usr=}}{{26688098 }} gab.com Text Recapitulation of complex transport and action of drugs at the tumor microenvironment using tumor-microenvironment-on-chip JO: Cancer Lett http://www.kidney.de/pget.php?&tw=1&pmid=26688098 #FOAvip Targeted delivery aims to selectively distribute drugs to targeted tumor tissues but not to healthy tissues. This can address many clinical challenges by maximizing the efficacy but minimizing the toxicity of anti-cancer drugs. However, a complex tumor microenvironment poses various barriers hindering the transport of drugs and drug delivery systems. New tumor models that allow for the systematic study of these complex environments are highly desired to provide reliable test beds to develop drug delivery systems for targeted delivery. Recently, research efforts have yielded new in vitro tumor models, the so called tumor-microenvironment-on-chip, that recapitulate certain characteristics of the tumor microenvironment. These new models show benefits over other conventional tumor models, and have the potential to accelerate drug discovery and enable precision medicine. However, further research is warranted to overcome their limitations and to properly interpret the data obtained from these models. In this article, key features of the in vivo tumor microenvironment that are relevant to drug transport processes for targeted delivery were discussed, and the current status and challenges for developing in vitro transport model systems were reviewed. Twit Text FOAVip Recapitulation of complex transport and action of drugs at the tumor microenvironment using tumor-microenvironment-on-chip ????Cancer Lett http://www.kidney.de/pget.php?&tw=1&pmid=26688098 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26688098 #FOAvip English Wikipedia <ref>{{Cite pmid|26688098 }}</ref> Recapitulation of complex transport and action of drugs at the tumor microenvironment using tumor-microenvironment-on-chip #MMPMID26688098 Han B ; Qu C ; Park K ; Konieczny SF ; Korc M Cancer Lett 2016[Sep]; 380 (1 ): 319-29 PMID26688098 show ga Targeted delivery aims to selectively distribute drugs to targeted tumor tissues but not to healthy tissues. This can address many clinical challenges by maximizing the efficacy but minimizing the toxicity of anti-cancer drugs. However, a complex tumor microenvironment poses various barriers hindering the transport of drugs and drug delivery systems. New tumor models that allow for the systematic study of these complex environments are highly desired to provide reliable test beds to develop drug delivery systems for targeted delivery. Recently, research efforts have yielded new in vitro tumor models, the so called tumor-microenvironment-on-chip, that recapitulate certain characteristics of the tumor microenvironment. These new models show benefits over other conventional tumor models, and have the potential to accelerate drug discovery and enable precision medicine. However, further research is warranted to overcome their limitations and to properly interpret the data obtained from these models. In this article, key features of the in vivo tumor microenvironment that are relevant to drug transport processes for targeted delivery were discussed, and the current status and challenges for developing in vitro transport model systems were reviewed. |*Lab-On-A-Chip Devices [MESH] |*Microchip Analytical Procedures [MESH] |*Tumor Microenvironment [MESH] |Animals [MESH] |Antineoplastic Agents/*administration & dosage [MESH] |Biological Transport [MESH] |Carcinoma, Pancreatic Ductal/*drug therapy/metabolism/pathology [MESH] |Cell Proliferation/drug effects [MESH] |Drug Carriers [MESH] |Drug Delivery Systems/*methods [MESH] |Drug Discovery/instrumentation/methods [MESH] |Drug Resistance, Neoplasm [MESH] |Humans [MESH] |Microfluidic Analytical Techniques/instrumentation [MESH] |Micromanipulation/instrumentation [MESH] |Molecular Targeted Therapy [MESH]Recapitulation of complex transport and action of drugs at the tumor (epmc).pdf DeepDyve Pubget Overpricing