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10.1161/CIRCRESAHA.116.308807 http://scihub22266oqcxt.onion/10.1161/CIRCRESAHA.116.308807 C4902745!4902745!27166251     free     free     free Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Circ+Res 2016 ; 118 (12): e36-42 Nephropedia Template TP {{tp|p=27166251|t=2016. Proton Pump Inhibitors Accelerate Endothelial Senescence |pdf=|usr=}}{{27166251}} gab.com Text Proton Pump Inhibitors Accelerate Endothelial Senescence JO: Circ Res http://www.kidney.de/pget.php?&tw=1&pmid=27166251 #FOAvip Rationale: Proton pump inhibitors (PPIs) are popular drugs for gastroesophageal reflux, now available for long-term use without medical supervision. Recent reports suggest that PPI use is associated with cardiovascular, renal and neurological morbidity. Objective: To study the long-term effect of PPIs on endothelial dysfunction and senescence and investigate the mechanism involved in PPI induced vascular dysfunction. Methods and Results: Chronic exposure to PPIs impaired endothelial function and accelerated human endothelial senescence by reducing telomere length. Conclusion: Our data may provide a unifying mechanism for the association of PPI use with increased risk of cardiovascular, renal and neurological morbidity and mortality. Twit Text FOAVip Proton Pump Inhibitors Accelerate Endothelial Senescence ????Circ Res http://www.kidney.de/pget.php?&tw=1&pmid=27166251 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27166251 #FOAvip English Wikipedia <ref>{{Cite pmid|27166251}}</ref> Proton Pump Inhibitors Accelerate Endothelial Senescence #MMPMID27166251 Yepuri G; Sukhovershin R; Nazari-Shafti TZ; Petrascheck M; Ghebre YT; Cooke JP Circ Res 2016[Jun]; 118 (12): e36-42 PMID27166251show ga Rationale: Proton pump inhibitors (PPIs) are popular drugs for gastroesophageal reflux, now available for long-term use without medical supervision. Recent reports suggest that PPI use is associated with cardiovascular, renal and neurological morbidity. Objective: To study the long-term effect of PPIs on endothelial dysfunction and senescence and investigate the mechanism involved in PPI induced vascular dysfunction. Methods and Results: Chronic exposure to PPIs impaired endothelial function and accelerated human endothelial senescence by reducing telomere length. Conclusion: Our data may provide a unifying mechanism for the association of PPI use with increased risk of cardiovascular, renal and neurological morbidity and mortality. äProton Pump Inhibitors Accelerate Endothelial Senescence (epmc).pdf DeepDyve Pubget Overpricing