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2016 ; 95
(20
): e3431
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Clinical Outcomes for Systemic Corticosteroids Versus Vincristine in Treating
Kaposiform Hemangioendothelioma and Tufted Angioma
#MMPMID27196448
Liu X
; Li J
; Qu X
; Yan W
; Zhang L
; Zhang S
; Yang C
; Zheng J
Medicine (Baltimore)
2016[May]; 95
(20
): e3431
PMID27196448
show ga
A meta-analysis was performed to evaluate the efficacy and safety of systemic
corticosteroids versus those of vincristine in the treatment of kaposiform
hemangioendothelioma (KHE) and tufted angioma (TA).A literature search of PubMed,
Embase, and Web of Science was performed for clinical studies on systemic
corticosteroid versus vincristine therapies in treating KHE/TA. Pooled relative
risks (RRs) and response rate with 95% confidence intervals (CIs) were used to
measure outcomes. Heterogeneity, subgroup analysis, sensitivity analysis, and
publication bias analysis were performed for result evaluation.Thirteen studies,
comprising 344 participants, were used in the analysis. Vincristine therapy was
found to be relatively more effective than systemic corticosteroids (RRs?=?0.45,
95%CI: 0.35-0.58). The result of pooled adverse reactions response rate for
systemic corticosteroids was 0.31 (95%CI, 0.18-0.43), significantly higher than
that for vincristine, which was 0.12 (95%CI, 0.06-0.19). In subgroup analyses,
factors including mean age and race of patients, and period of follow-up were
examined as possible sources of heterogeneity.This is the first meta-analysis
estimating the clinical outcomes of systemic corticosteroids in comparison with
those of vincristine in the treatment of KHE/TA. The results showed that
vincristine was considerably more effective with lower complication rates than
systemic corticosteroids; thus, vincristine could be suggested as the first-line
therapy for KHE/TA.