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10.1371/journal.pone.0157395 http://scihub22266oqcxt.onion/10.1371/journal.pone.0157395 C4902269!4902269 !27284976     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=27284976 &cmd=llinks): Failed to open stream: HTTP request failed! 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The Transcriptional Repressor Gfi1 Plays a Critical Role in the Development of NKT1- and NKT2-Type iNKT Cells |pdf=|usr=}}{{27284976 }} gab.com Text The Transcriptional Repressor Gfi1 Plays a Critical Role in the Development of NKT1- and NKT2-Type iNKT Cells JO: PLoS One http://www.kidney.de/pget.php?&tw=1&pmid=27284976 #FOAvip Gfi1 plays an important role in the development and maintenance of many hematopoietic linage cells. However, the impact of Gfi1-deficiency on the iNKT cell differentiation remains unclear. We herein demonstrate a critical role of Gfi1 in regulating the development of iNKT cell subsets. In the thymus of T cell-specific Gfi1-deficient mice, iNKT cells normally developed up to stage 2, while the number of stage 3 NK1.1pos iNKT cells was significantly reduced. Furthermore, CD4pos iNKT cells were selectively reduced in the peripheral organs of T cell-specific Gfi1-deficient mice. The ?-GalCer-dependent production of IFN-?and Th2 cytokines, but not IL-17A, was severely reduced in T cell-specific Gfi1-deficient mice. In addition, a reduction of the ?-GalCer-induced anti-tumor activity was observed in Gfi1-deficient mice. These findings demonstrate the important role of Gfi1 in regulating the development and function of NKT1- and NKT2-type iNKT cell subsets. Twit Text FOAVip The Transcriptional Repressor Gfi1 Plays a Critical Role in the Development of NKT1- and NKT2-Type iNKT Cells ????PLoS One http://www.kidney.de/pget.php?&tw=1&pmid=27284976 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27284976 #FOAvip English Wikipedia <ref>{{Cite pmid|27284976 }}</ref> The Transcriptional Repressor Gfi1 Plays a Critical Role in the Development of NKT1- and NKT2-Type iNKT Cells #MMPMID27284976 Yasuoka T ; Kuwahara M ; Yamada T ; Maruyama S ; Suzuki J ; Taniguchi M ; Yasukawa M ; Yamashita M PLoS One 2016[]; 11 (6 ): e0157395 PMID27284976 show ga Gfi1 plays an important role in the development and maintenance of many hematopoietic linage cells. However, the impact of Gfi1-deficiency on the iNKT cell differentiation remains unclear. We herein demonstrate a critical role of Gfi1 in regulating the development of iNKT cell subsets. In the thymus of T cell-specific Gfi1-deficient mice, iNKT cells normally developed up to stage 2, while the number of stage 3 NK1.1pos iNKT cells was significantly reduced. Furthermore, CD4pos iNKT cells were selectively reduced in the peripheral organs of T cell-specific Gfi1-deficient mice. The ?-GalCer-dependent production of IFN-?and Th2 cytokines, but not IL-17A, was severely reduced in T cell-specific Gfi1-deficient mice. In addition, a reduction of the ?-GalCer-induced anti-tumor activity was observed in Gfi1-deficient mice. These findings demonstrate the important role of Gfi1 in regulating the development and function of NKT1- and NKT2-type iNKT cell subsets. |Animals [MESH] |Antigens, Ly/immunology [MESH] |CD4 Antigens/immunology [MESH] |Cell Differentiation [MESH] |Cytokines/immunology [MESH] |DNA-Binding Proteins/genetics/*immunology [MESH] |Galactosylceramides/immunology [MESH] |Gene Deletion [MESH] |Gene Knock-In Techniques [MESH] |Interferon-gamma/immunology [MESH] |Lung Neoplasms/genetics/immunology [MESH] |Melanoma, Experimental/genetics/immunology [MESH] |Mice [MESH] |NK Cell Lectin-Like Receptor Subfamily B/immunology [MESH] |Natural Killer T-Cells/cytology/*immunology [MESH]The Transcriptional Repressor Gfi1 Plays a Critical Role in the Develo(epmc).pdf DeepDyve Pubget Overpricing