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10.1371/journal.pone.0157251 http://scihub22266oqcxt.onion/10.1371/journal.pone.0157251 C4902235!4902235 !27285995     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=27285995 &cmd=llinks): Failed to open stream: HTTP request failed! 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Anti-Breast Cancer Potential of Quercetin via the Akt/AMPK/Mammalian Target of Rapamycin (mTOR) Signaling Cascade |pdf=|usr=}}{{27285995 }} gab.com Text Anti-Breast Cancer Potential of Quercetin via the Akt/AMPK/Mammalian Target of Rapamycin (mTOR) Signaling Cascade JO: PLoS One http://www.kidney.de/pget.php?&tw=1&pmid=27285995 #FOAvip The Akt/adenosine monophosphate protein kinase (AMPK)/mammalian target of rapamycin (mTOR) pathway has emerged as a critical signaling nexus for regulating cellular metabolism, energy homeostasis, and cell growth. Thus, dysregulation of this pathway contributes to the development of metabolic disorders such as obesity, type 2diabetes, and cancer. We previously reported that a combination of grape polyphenols (resveratrol, quercetin and catechin: RQC), at equimolar concentrations, reduces breast cancer (BC) growth and metastasis in nude mice, and inhibits Akt and mTOR activities and activates AMPK, an endogenous inhibitor of mTOR, in metastatic BC cells. The objective of the present study was to determine the contribution of individual polyphenols to the effect of combined RQC on mTOR signaling. Metastatic BC cells were treated with RQC individually or in combination, at various concentrations, and the activities (phosphorylation) of AMPK, Akt, and the mTOR downstream effectors, p70S6 kinase (p70S6K) and 4E binding protein (4EBP1), were determined by Western blot. Results show that quercetin was the most effective compound for Akt/mTOR inhibition. Treatment with quercetin at 15?M had a similar effect as the RQC combination in the inhibition of BC cell proliferation, apoptosis, and migration. However, cell cycle analysis showed that the RQC treatment arrested BC cells in the G1 phase, while quercetin arrested the cell cycle in G2/M. In vivo experiments, using SCID mice with implanted tumors from metastatic BC cells, demonstrated that administration of quercetin at 15mg/kg body weight resulted in a ~70% reduction in tumor growth. In conclusion, quercetin appears to be a viable grape polyphenol for future development as an anti BC therapeutic. Twit Text FOAVip Anti-Breast Cancer Potential of Quercetin via the Akt/AMPK/Mammalian Target of Rapamycin (mTOR) Signaling Cascade ????PLoS One http://www.kidney.de/pget.php?&tw=1&pmid=27285995 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27285995 #FOAvip English Wikipedia <ref>{{Cite pmid|27285995 }}</ref> Anti-Breast Cancer Potential of Quercetin via the Akt/AMPK/Mammalian Target of Rapamycin (mTOR) Signaling Cascade #MMPMID27285995 Rivera Rivera A ; Castillo-Pichardo L ; Gerena Y ; Dharmawardhane S PLoS One 2016[]; 11 (6 ): e0157251 PMID27285995 show ga The Akt/adenosine monophosphate protein kinase (AMPK)/mammalian target of rapamycin (mTOR) pathway has emerged as a critical signaling nexus for regulating cellular metabolism, energy homeostasis, and cell growth. Thus, dysregulation of this pathway contributes to the development of metabolic disorders such as obesity, type 2diabetes, and cancer. We previously reported that a combination of grape polyphenols (resveratrol, quercetin and catechin: RQC), at equimolar concentrations, reduces breast cancer (BC) growth and metastasis in nude mice, and inhibits Akt and mTOR activities and activates AMPK, an endogenous inhibitor of mTOR, in metastatic BC cells. The objective of the present study was to determine the contribution of individual polyphenols to the effect of combined RQC on mTOR signaling. Metastatic BC cells were treated with RQC individually or in combination, at various concentrations, and the activities (phosphorylation) of AMPK, Akt, and the mTOR downstream effectors, p70S6 kinase (p70S6K) and 4E binding protein (4EBP1), were determined by Western blot. Results show that quercetin was the most effective compound for Akt/mTOR inhibition. Treatment with quercetin at 15?M had a similar effect as the RQC combination in the inhibition of BC cell proliferation, apoptosis, and migration. However, cell cycle analysis showed that the RQC treatment arrested BC cells in the G1 phase, while quercetin arrested the cell cycle in G2/M. In vivo experiments, using SCID mice with implanted tumors from metastatic BC cells, demonstrated that administration of quercetin at 15mg/kg body weight resulted in a ~70% reduction in tumor growth. In conclusion, quercetin appears to be a viable grape polyphenol for future development as an anti BC therapeutic. |AMP-Activated Protein Kinases/metabolism [MESH] |Animals [MESH] |Antineoplastic Agents, Phytogenic/chemistry/pharmacology/*therapeutic use [MESH] |Breast Neoplasms/*drug therapy/metabolism/pathology [MESH] |Breast/*drug effects/metabolism/pathology [MESH] |Catechin/chemistry/pharmacology/*therapeutic use [MESH] |Cell Cycle/drug effects [MESH] |Cell Line, Tumor [MESH] |Cell Proliferation/drug effects [MESH] |Female [MESH] |Humans [MESH] |Mice, Nude [MESH] |Mice, SCID [MESH] |Neoplasm Metastasis/pathology/prevention & control [MESH] |Proto-Oncogene Proteins c-akt/metabolism [MESH] |Quercetin/chemistry/pharmacology/*therapeutic use [MESH] |Resveratrol [MESH] |Signal Transduction/*drug effects [MESH] |Stilbenes/chemistry/pharmacology/*therapeutic use [MESH] |TOR Serine-Threonine Kinases/metabolism [MESH]Anti-Breast Cancer Potential of Quercetin via the Akt/AMPK/Mammalian T(epmc).pdf DeepDyve Pubget Overpricing