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10.1126/science.aad0217 http://scihub22266oqcxt.onion/10.1126/science.aad0217 C4902127!4902127!26494171     free     free     free       Science 2015 ; 350 (6262): 815-20 Nephropedia Template TP {{tp|p=26494171|t=2015. microRNA-encoded behaviour in Drosophila+ |pdf=|usr=}}{{26494171}} gab.com Text microRNA-encoded behaviour in Drosophila+ JO: Science http://www.kidney.de/pget.php?&tw=1&pmid=26494171 #FOAvip The relationship between microRNA regulation and the specification of behaviour is only beginning to be explored. Here we find that mutation of a single microRNA locus (miR-iab4/8) in Drosophila larvae affects the animal?s capacity to correct its orientation if turned upside-down (self-righting). One of the microRNA targets involved in this behaviour is the Hox gene Ultrabithorax whose derepression in two metameric neurons leads to self-righting defects. In vivo neural activity analysis reveals that these neurons, the self-righting node (SRN), have different activity patterns in wild type and miRNA mutants whilst thermogenetic manipulation of SRN activity results in changes in self-righting behaviour. Our work thus reveals a microRNA-encoded behaviour and suggests that other microRNAs might also be involved in behavioural control in Drosophila and other species. Twit Text FOAVip microRNA-encoded behaviour in Drosophila+ ????Science http://www.kidney.de/pget.php?&tw=1&pmid=26494171 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26494171 #FOAvip English Wikipedia <ref>{{Cite pmid|26494171}}</ref> microRNA-encoded behaviour in Drosophila+ #MMPMID26494171 Picao-Osorio J; Johnston J; Landgraf M; Berni J; Alonso CR Science 2015[Nov]; 350 (6262): 815-20 PMID26494171show ga The relationship between microRNA regulation and the specification of behaviour is only beginning to be explored. Here we find that mutation of a single microRNA locus (miR-iab4/8) in Drosophila larvae affects the animal?s capacity to correct its orientation if turned upside-down (self-righting). One of the microRNA targets involved in this behaviour is the Hox gene Ultrabithorax whose derepression in two metameric neurons leads to self-righting defects. In vivo neural activity analysis reveals that these neurons, the self-righting node (SRN), have different activity patterns in wild type and miRNA mutants whilst thermogenetic manipulation of SRN activity results in changes in self-righting behaviour. Our work thus reveals a microRNA-encoded behaviour and suggests that other microRNAs might also be involved in behavioural control in Drosophila and other species. ämicroRNA-encoded behaviour in Drosophila+ (epmc).pdf DeepDyve Pubget Overpricing