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10.3892/ijo.2016.3512 http://scihub22266oqcxt.onion/10.3892/ijo.2016.3512 C4902079!4902079 !27177126     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\27177126 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Int+J+Oncol 2016 ; 49 (1 ): 99-110 Nephropedia Template TP {{tp|p=27177126 |t=2016. Verapamil inhibits tumor progression of chemotherapy-resistant pancreatic cancer side population cells |pdf=|usr=}}{{27177126 }} gab.com Text Verapamil inhibits tumor progression of chemotherapy-resistant pancreatic cancer side population cells JO: Int J Oncol http://www.kidney.de/pget.php?&tw=1&pmid=27177126 #FOAvip Tumor side population (SP) cells display stem-like properties that can be modulated by treatment with the calcium channel blocker verapamil. Verapamil can enhance the cytotoxic effects of chemotherapeutic drugs and multidrug resistance by targeting the transport function of the P-glycoprotein (P-gp). This study focused on the therapeutic potential of verapamil on stem-like SP tumor cells, and further investigated its chemosensitizing effects using L3.6pl and AsPC-1 pancreatic carcinoma models. As compared to parental L3.6pl cells (0.9±0.22%), L3.6pl gemcitabine-resistant cells (L3.6plGres) showed a significantly higher percentage of SP cells (5.38±0.99%) as detected by Hoechst 33342/FACS assays. The L3.6plGres SP cells showed stable gemcitabine resistance, enhanced colony formation ability and increased tumorigenicity. Verapamil effectively inhibited L3.6plGres and AsPC-1 SP cell proliferation in vitro. A pro-apoptotic effect of verapamil was observed in L3.6pl cells, but not in L3.6plGres cells, which was linked to their differential expression of P-gp and equilibrative nucleoside transporter-1 (ENT-1). In an orthotopic pancreatic cancer mouse model, both low and high dose verapamil was shown to substantially reduce L3.6plGres-SP cell tumor growth and metastasis, enhance tumor apoptosis, and reduce microvascular density. Twit Text FOAVip Verapamil inhibits tumor progression of chemotherapy-resistant pancreatic cancer side population cells ????Int J Oncol http://www.kidney.de/pget.php?&tw=1&pmid=27177126 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27177126 #FOAvip English Wikipedia <ref>{{Cite pmid|27177126 }}</ref> Verapamil inhibits tumor progression of chemotherapy-resistant pancreatic cancer side population cells #MMPMID27177126 Zhao L ; Zhao Y ; Schwarz B ; Mysliwietz J ; Hartig R ; Camaj P ; Bao Q ; Jauch KW ; Guba M ; Ellwart JW ; Nelson PJ ; Bruns CJ Int J Oncol 2016[Jul]; 49 (1 ): 99-110 PMID27177126 show ga Tumor side population (SP) cells display stem-like properties that can be modulated by treatment with the calcium channel blocker verapamil. Verapamil can enhance the cytotoxic effects of chemotherapeutic drugs and multidrug resistance by targeting the transport function of the P-glycoprotein (P-gp). This study focused on the therapeutic potential of verapamil on stem-like SP tumor cells, and further investigated its chemosensitizing effects using L3.6pl and AsPC-1 pancreatic carcinoma models. As compared to parental L3.6pl cells (0.9±0.22%), L3.6pl gemcitabine-resistant cells (L3.6plGres) showed a significantly higher percentage of SP cells (5.38±0.99%) as detected by Hoechst 33342/FACS assays. The L3.6plGres SP cells showed stable gemcitabine resistance, enhanced colony formation ability and increased tumorigenicity. Verapamil effectively inhibited L3.6plGres and AsPC-1 SP cell proliferation in vitro. A pro-apoptotic effect of verapamil was observed in L3.6pl cells, but not in L3.6plGres cells, which was linked to their differential expression of P-gp and equilibrative nucleoside transporter-1 (ENT-1). In an orthotopic pancreatic cancer mouse model, both low and high dose verapamil was shown to substantially reduce L3.6plGres-SP cell tumor growth and metastasis, enhance tumor apoptosis, and reduce microvascular density. |ATP Binding Cassette Transporter, Subfamily B, Member 1/*biosynthesis [MESH] |Animals [MESH] |Apoptosis/drug effects [MESH] |Cell Proliferation/drug effects [MESH] |Drug Resistance, Neoplasm/*genetics [MESH] |Equilibrative Nucleoside Transporter 1/*biosynthesis/genetics [MESH] |Gene Expression Regulation, Neoplastic/drug effects [MESH] |Humans [MESH] |Mice [MESH] |Pancreatic Neoplasms/*drug therapy/genetics/pathology [MESH] |Side-Population Cells/drug effects [MESH] |Verapamil/*administration & dosage [MESH]Verapamil inhibits tumor progression of chemotherapy-resistant pancrea(epmc).pdf DeepDyve Pubget Overpricing