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Metabolism of TH17 Cells: New Insights and Therapeutic Opportunities #MMPMID26893133
Wang R; Solt LA
Eur J Immunol 2016[Apr]; 46 (4): 807-16 PMID26893133show ga
An effective adaptive immune response relies on the ability of lymphocytes to rapidly act upon a variety of infectious insults. In T lymphocytes, this response includes cell growth, clonal expansion, differentiation, and cytokine production, all of which places a significant energy burden on the cell. As a result, T cells engage specific metabolic pathways to carry out their effector functions. Recent insights have demonstrated that T-cell metabolic reprogramming is an essential component of the adaptive immune response and specific metabolic pathways dictate T-cell fate decisions, including the development of TH17 versus T regulatory (Treg) cells. TH17 cells have garnered significant attention since their discovery nearly a decade ago due to their roles in the pathology of several immune-mediated inflammatory diseases. Attempts to fully characterize TH17 cells have demonstrated that they are highly dynamic, adjusting their function to environmental cues which dictates the metabolic program of the cell. In this short review, we will highlight recent data demonstrating the impact of cellular metabolism on the TH17/Treg balance and present factors that mediate TH17 cell metabolism. Finally, we discuss the potential therapeutic options and the implications of modulating TH17 cell metabolism for the treatment of TH17-mediated diseases.
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Eur+J+Immunol 2016 ; 46 (4): 807-16
