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10.1007/s00412-015-0539-4 http://scihub22266oqcxt.onion/10.1007/s00412-015-0539-4 C4901126!4901126!26453572     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Chromosoma 2016 ; 125 (ä): 471-96 Nephropedia Template TP {{tp|p=26453572|t=2016. The quest for mammalian Polycomb response elements: are we there yet?|pdf=|usr=}}{{26453572}} gab.com Text The quest for mammalian Polycomb response elements: are we there yet JO: Chromosoma http://www.kidney.de/pget.php?&tw=1&pmid=26453572 #FOAvip A long-standing mystery in the field of Polycomb and Trithorax regulation is how these proteins, which are highly conserved between flies and mammals, can regulate several hundred equally highly conserved target genes, but recognise these targets via cis-regulatory elements that appear to show no conservation in their DNA sequence. These elements, termed Polycomb/Trithorax response elements (PRE/TREs or PREs), are relatively well characterised in flies, but their mammalian counterparts have proved to be extremely difficult to identify. Recent progress in this endeavour has generated a wealth of data and raised several intriguing questions. Here, we ask why and to what extent mammalian PREs are so different to those of the fly. We review recent advances, evaluate current models and identify open questions in the quest for mammalian PREs.Electronic supplementary material: The online version of this article (doi:10.1007/s00412-015-0539-4) contains supplementary material, which is available to authorized users. Twit Text FOAVip The quest for mammalian Polycomb response elements: are we there yet ????Chromosoma http://www.kidney.de/pget.php?&tw=1&pmid=26453572 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26453572 #FOAvip English Wikipedia <ref>{{Cite pmid|26453572}}</ref> The quest for mammalian Polycomb response elements: are we there yet? #MMPMID26453572 Bauer M; Trupke J; Ringrose L Chromosoma 2016[]; 125 (ä): 471-96 PMID26453572show ga A long-standing mystery in the field of Polycomb and Trithorax regulation is how these proteins, which are highly conserved between flies and mammals, can regulate several hundred equally highly conserved target genes, but recognise these targets via cis-regulatory elements that appear to show no conservation in their DNA sequence. These elements, termed Polycomb/Trithorax response elements (PRE/TREs or PREs), are relatively well characterised in flies, but their mammalian counterparts have proved to be extremely difficult to identify. Recent progress in this endeavour has generated a wealth of data and raised several intriguing questions. Here, we ask why and to what extent mammalian PREs are so different to those of the fly. We review recent advances, evaluate current models and identify open questions in the quest for mammalian PREs.Electronic supplementary material: The online version of this article (doi:10.1007/s00412-015-0539-4) contains supplementary material, which is available to authorized users. äThe quest for mammalian Polycomb response elements: are we there yet?(epmc).pdf DeepDyve Pubget Overpricing