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10.1021/acschembio.5b00966 http://scihub22266oqcxt.onion/10.1021/acschembio.5b00966 C4900815!4900815!26629587     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       ACS+Chem+Biol 2016 ; 11 (2): 319-23 Nephropedia Template TP {{tp|p=26629587|t=2016. Boronic Acid for the Traceless Delivery of Proteins into Cells |pdf=|usr=}}{{26629587}} gab.com Text Boronic Acid for the Traceless Delivery of Proteins into Cells JO: ACS Chem Biol http://www.kidney.de/pget.php?&tw=1&pmid=26629587 #FOAvip The use of exogenous proteins as intracellular probes and chemotherapeutic agents is in its infancy. A major hurdle has been the delivery of native proteins to an intracellular site of action. Herein, we report on a compact delivery vehicle that employs the intrinsic affinity of boronic acids for the carbohydrates that coat the surface of mammalian cells. In the vehicle, benzoxaborole is linked to protein amino groups via a ?trimethyl lock?. Immolation of this linker is triggered by cellular esterases, releasing native protein. Efficacy is demonstrated by enhanced delivery of green fluorescent protein and a cytotoxic ribonuclease into mammalian cells. This versatile strategy provides new opportunities in chemical biology and pharmacology. Twit Text FOAVip Boronic Acid for the Traceless Delivery of Proteins into Cells ????ACS Chem Biol http://www.kidney.de/pget.php?&tw=1&pmid=26629587 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26629587 #FOAvip English Wikipedia <ref>{{Cite pmid|26629587}}</ref> Boronic Acid for the Traceless Delivery of Proteins into Cells #MMPMID26629587 Andersen KA; Smith TP; Lomax JE; Raines RT ACS Chem Biol 2016[Feb]; 11 (2): 319-23 PMID26629587show ga The use of exogenous proteins as intracellular probes and chemotherapeutic agents is in its infancy. A major hurdle has been the delivery of native proteins to an intracellular site of action. Herein, we report on a compact delivery vehicle that employs the intrinsic affinity of boronic acids for the carbohydrates that coat the surface of mammalian cells. In the vehicle, benzoxaborole is linked to protein amino groups via a ?trimethyl lock?. Immolation of this linker is triggered by cellular esterases, releasing native protein. Efficacy is demonstrated by enhanced delivery of green fluorescent protein and a cytotoxic ribonuclease into mammalian cells. This versatile strategy provides new opportunities in chemical biology and pharmacology. äBoronic Acid for the Traceless Delivery of Proteins into Cells (epmc).pdf DeepDyve Pubget Overpricing