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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Ann+Card+Anaesth
2015 ; 18
(1
): 29-33
Nephropedia Template TP
Thimmarayappa A
; Chandrasekaran N
; Jagadeesh AM
; Joshi SS
Ann Card Anaesth
2015[Jan]; 18
(1
): 29-33
PMID25566708
show ga
AIMS: The aim of the study was to measure airway patency objectively during
dexmedetomidine sedation under radiographic guidance in spontaneously breathing
pediatric patients scheduled for cardiac catheterization procedures. SUBJECTS AND
METHODS: Thirty-five patients in the age group 5-10 years scheduled for cardiac
catheterization procedures were enrolled. All study patients were given loading
dose of dexmedetomidine at 1 mg/kg/min for 10 min and then maintenance dose of
1.5 mg/kg/h. Radiographic airway patency was assessed at the start of infusion (0
min) and after 30 min. Antero-posterior (AP) diameters were measured manually at
the nasopharyngeal and retroglossal levels. Dynamic change in airway between
inspiration and expiration was considered a measure of airway collapsibility.
Patients were monitored for hemodynamics, recovery time and complications.
STATISTICAL ANALYSIS: Student paired t-test was used for data analysis. P < 0.05
was considered significant. RESULTS: Minimum and maximum AP diameters were
compared at 0 and 30 min. Nasopharyngeal level showed significant reduction in
the minimum (6.27 ± 1.09 vs. 4.26 ± 1.03, P < 0.0001) and maximum (6.51 ± 1.14
vs. 5.99 ± 1.03, P < 0.0001) diameters. Similarly retroglossal level showed
significant reduction in the minimum (6.98 ± 1.09 vs. 5.27 ± 1.15, P < 0.0001)
and maximum (7.49 ± 1.22 vs. 6.92 ± 1.12, P < 0.0003) diameters. The degree of
collapsibility was greater at 30 min than baseline ( P < 0.0001). There was a
significant decrease in heart rate ( P < 0.0001), and the average recovery time
was 39.86 ± 12.22 min. CONCLUSION: Even though airway patency was maintained in
all children sedated with dexmedetomidine, there were significant reductions in
the upper airway dimensions measured, so all precautions to manage the airway
failure should be taken.