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10.4103/0971-9784.148331

http://scihub22266oqcxt.onion/10.4103/0971-9784.148331
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C4900302!4900302!25566721
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suck abstract from ncbi


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pmid25566721      Ann+Card+Anaesth 2015 ; 18 (1): 101-3
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  • Intractable hyperkalemia due to nicorandil induced potassium channel syndrome #MMPMID25566721
  • Chowdhry V; Mohanty BB
  • Ann Card Anaesth 2015[Jan]; 18 (1): 101-3 PMID25566721show ga
  • Nicorandil is a commonly used antianginal agent, which has both nitrate-like and ATP-sensitive potassium (KATP) channel activator properties. Activation of potassium channels by nicorandil causes expulsion of potassium ions into the extracellular space leading to membrane hyperpolarization, closure of voltage-gated calcium channels and finally vasodilatation. However, on the other hand, being an activator of KATP channel, it can expel K+ ions out of the cells and can cause hyperkalemia. Here, we report a case of nicorandil induced hyperkalemia unresponsive to medical treatment in a patient with diabetic nephropathy.
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