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Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Ann+Card+Anaesth 2015 ; 18 (1): 101-3 Nephropedia Template TP
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Intractable hyperkalemia due to nicorandil induced potassium channel syndrome #MMPMID25566721
Chowdhry V; Mohanty BB
Ann Card Anaesth 2015[Jan]; 18 (1): 101-3 PMID25566721show ga
Nicorandil is a commonly used antianginal agent, which has both nitrate-like and ATP-sensitive potassium (KATP) channel activator properties. Activation of potassium channels by nicorandil causes expulsion of potassium ions into the extracellular space leading to membrane hyperpolarization, closure of voltage-gated calcium channels and finally vasodilatation. However, on the other hand, being an activator of KATP channel, it can expel K+ ions out of the cells and can cause hyperkalemia. Here, we report a case of nicorandil induced hyperkalemia unresponsive to medical treatment in a patient with diabetic nephropathy.