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10.1089/ars.2015.6415

http://scihub22266oqcxt.onion/10.1089/ars.2015.6415
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C4900226!4900226!27139586
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suck abstract from ncbi


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pmid27139586      Antioxid+Redox+Signal 2016 ; 24 (16): 939-58
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  • Imaging Reactive Oxygen Species-Induced Modifications in Living Systems #MMPMID27139586
  • Maulucci G; Ba?i? G; Bridal L; Schmidt HH; Tavitian B; Viel T; Utsumi H; Yalç?n AS; De Spirito M
  • Antioxid Redox Signal 2016[Jun]; 24 (16): 939-58 PMID27139586show ga
  • Significance: Reactive Oxygen Species (ROS) may regulate signaling, ion channels, transcription factors, and biosynthetic processes. ROS-related diseases can be due to either a shortage or an excess of ROS. Recent Advances: Since the biological activity of ROS depends on not only concentration but also spatiotemporal distribution, real-time imaging of ROS, possibly in vivo, has become a need for scientists, with potential for clinical translation. New imaging techniques as well as new contrast agents in clinically established modalities were developed in the previous decade. Critical Issues: An ideal imaging technique should determine ROS changes with high spatio-temporal resolution, detect physiologically relevant variations in ROS concentration, and provide specificity toward different redox couples. Furthermore, for in vivo applications, bioavailability of sensors, tissue penetration, and a high signal-to-noise ratio are additional requirements to be satisfied. Future Directions: None of the presented techniques fulfill all requirements for clinical translation. The obvious way forward is to incorporate anatomical and functional imaging into a common hybrid-imaging platform. Antioxid. Redox Signal. 24, 939?958.
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