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10.4103/0253-7613.182884

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suck abstract from ncbi


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pmid27298500
      Indian+J+Pharmacol 2016 ; 48 (3 ): 292-7
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  • Weekly injection of histaglobulin produces long-term remission in chronic urticaria: A prospective clinical study #MMPMID27298500
  • Rajesh G ; Keerthi S ; Karthikeyan K ; Venkatesan M
  • Indian J Pharmacol 2016[May]; 48 (3 ): 292-7 PMID27298500 show ga
  • OBJECTIVE: Treatment of chronic urticaria (CU) can be difficult in many patients. Achieving long-term remission and reducing the requirement of antihistamines are vital in CU. The objective of this study was to assess the effectiveness of injection histaglobulin, a complex of histamine and human immunoglobulin, in producing relief in patients with CU. MATERIALS AND METHODS: Fifty-one patients with CU were enrolled into this prospective clinical study. Patients were administered 1 ml of injection histaglobulin subcutaneous for 8 consecutive weeks. They were also prescribed tablet levocetirizine 5 mg to be taken when required (but not more than the permitted dosage). Efficacy was assessed using urticaria activity score (UAS) which has a maximum score of 33/day, during each weekly visit. Final assessment was done after 24 weeks. RESULTS: Twenty-nine patients had completed the entire 8-week drug regimen. Mean basal UAS was 18.9 ± 6.3 and it reduced to 80.4% by 8 weeks. The angioedema sub-score reduced by 89.8%. Anti-histamine pill burden also reduced significantly. By 24 weeks of starting the therapy, 23 patients (45%) had attained complete remission. No adverse effects to the drug were observed. CONCLUSIONS: Histaglobulin was found to be effective in producing long-term remission and it reduced the antihistamine requirement as well. Thus, it can serve as an effective alternative to existing treatment modalities.
  • |Adult [MESH]
  • |Chronic Disease [MESH]
  • |Drug Combinations [MESH]
  • |Female [MESH]
  • |Histamine/*administration & dosage [MESH]
  • |Humans [MESH]
  • |Male [MESH]
  • |Middle Aged [MESH]
  • |Prospective Studies [MESH]
  • |Urticaria/*drug therapy [MESH]


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