Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 249.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 249.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\27298500
.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Indian+J+Pharmacol
2016 ; 48
(3
): 292-7
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
Weekly injection of histaglobulin produces long-term remission in chronic
urticaria: A prospective clinical study
#MMPMID27298500
Rajesh G
; Keerthi S
; Karthikeyan K
; Venkatesan M
Indian J Pharmacol
2016[May]; 48
(3
): 292-7
PMID27298500
show ga
OBJECTIVE: Treatment of chronic urticaria (CU) can be difficult in many patients.
Achieving long-term remission and reducing the requirement of antihistamines are
vital in CU. The objective of this study was to assess the effectiveness of
injection histaglobulin, a complex of histamine and human immunoglobulin, in
producing relief in patients with CU. MATERIALS AND METHODS: Fifty-one patients
with CU were enrolled into this prospective clinical study. Patients were
administered 1 ml of injection histaglobulin subcutaneous for 8 consecutive
weeks. They were also prescribed tablet levocetirizine 5 mg to be taken when
required (but not more than the permitted dosage). Efficacy was assessed using
urticaria activity score (UAS) which has a maximum score of 33/day, during each
weekly visit. Final assessment was done after 24 weeks. RESULTS: Twenty-nine
patients had completed the entire 8-week drug regimen. Mean basal UAS was 18.9 ±
6.3 and it reduced to 80.4% by 8 weeks. The angioedema sub-score reduced by
89.8%. Anti-histamine pill burden also reduced significantly. By 24 weeks of
starting the therapy, 23 patients (45%) had attained complete remission. No
adverse effects to the drug were observed. CONCLUSIONS: Histaglobulin was found
to be effective in producing long-term remission and it reduced the antihistamine
requirement as well. Thus, it can serve as an effective alternative to existing
treatment modalities.