Applications of CRISPR-Cas systems in neuroscience #MMPMID26656253
Heidenreich M; Zhang F
Nat Rev Neurosci 2016[Jan]; 17 (1): 36-44 PMID26656253show ga
Genome editing tools, and in particular those based on CRISPR-Cas systems, are accelerating the pace of biological research and enabling targeted genetic interrogation in virtually any organism and cell type. These tools have opened the door to the development of new model systems for studying the complexity of the nervous system, including animal and stem cell-derived in vitro models. Precise and efficient gene editing using CRISPR-Cas systems has the potential to advance both basic and translational neuroscience research.