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10.1016/j.ahj.2016.03.007 http://scihub22266oqcxt.onion/10.1016/j.ahj.2016.03.007 C4899814!4899814!27264226     free     free     free Deprecated: Implicit conversion from float 225.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 225.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 225.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 225.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 225.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Am+Heart+J 2016 ; 176 (ä): 100-6 Nephropedia Template TP {{tp|p=27264226|t=2016. Asymmetric Dimethylarginine, Related Arginine Derivatives and Incident Atrial Fibrillation |pdf=|usr=}}{{27264226}} gab.com Text Asymmetric Dimethylarginine, Related Arginine Derivatives and Incident Atrial Fibrillation JO: Am Heart J http://www.kidney.de/pget.php?&tw=1&pmid=27264226 #FOAvip Background: Oxidative stress plays an important role in the development of atrial fibrillation (AF). Arginine derivatives including asymmetric dimethylarginine (ADMA) are central to nitric oxide metabolism and nitrosative stress. Whether blood concentrations of arginine derivatives are related to incidence of AF is uncertain. Methods and Results: In 3310 individuals (mean age 58±10 years, 54% women) from the community-based Framingham Study we prospectively examined the relations of circulating levels of ADMA, L-arginine, symmetric dimethylarginine (SDMA), and the ratio of L-arginine/ADMA to incidence of AF using proportional hazards regression models. Over a median follow-up time of 10 years 247 AF cases occurred.Using age- and sex-adjusted regression models, ADMA was associated with a hazard ratio of 1.15 per one standard deviation increase in loge-biomarker concentration (95% confidence interval 1.02 to 1.29, P=0.02) for AF, which was no longer significant after further risk factor adjustment (hazard ratio 1.09, 95% confidence interval 0.97 to 1.23, P=0.15). Neither L-arginine nor symmetric dimethylarginine was related to new-onset AF. A clinical model comprising clinical risk factors for AF (for age, sex, height, weight, systolic blood pressure, diastolic blood pressure, current smoking, diabetes, hypertension treatment, myocardial infarction, and heart failure) (C-statistic: 0.781; 95% confidence interval, 0.753 to 0.808) was not improved by the addition of ADMA (0.782; 95% confidence interval, 0.755 to 0.809). Conclusions: ADMA and related arginine derivatives were not associated with incident AF in the community after accounting for other clinical risk factors and confounders. Its role in the pathogenesis of AF needs further refinement. Twit Text FOAVip Asymmetric Dimethylarginine, Related Arginine Derivatives and Incident Atrial Fibrillation ????Am Heart J http://www.kidney.de/pget.php?&tw=1&pmid=27264226 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27264226 #FOAvip English Wikipedia <ref>{{Cite pmid|27264226}}</ref> Asymmetric Dimethylarginine, Related Arginine Derivatives and Incident Atrial Fibrillation #MMPMID27264226 Schnabel RB; Maas R; Wang N; Yin X; Larson MG; Levy D; Ellinor PT; Lubitz SA; McManus DD; Magnani JW; Atzler D; Böger RH; Schwedhelm E; Vasan RS; Benjamin EJ Am Heart J 2016[Jun]; 176 (ä): 100-6 PMID27264226show ga Background: Oxidative stress plays an important role in the development of atrial fibrillation (AF). Arginine derivatives including asymmetric dimethylarginine (ADMA) are central to nitric oxide metabolism and nitrosative stress. Whether blood concentrations of arginine derivatives are related to incidence of AF is uncertain. Methods and Results: In 3310 individuals (mean age 58±10 years, 54% women) from the community-based Framingham Study we prospectively examined the relations of circulating levels of ADMA, L-arginine, symmetric dimethylarginine (SDMA), and the ratio of L-arginine/ADMA to incidence of AF using proportional hazards regression models. Over a median follow-up time of 10 years 247 AF cases occurred.Using age- and sex-adjusted regression models, ADMA was associated with a hazard ratio of 1.15 per one standard deviation increase in loge-biomarker concentration (95% confidence interval 1.02 to 1.29, P=0.02) for AF, which was no longer significant after further risk factor adjustment (hazard ratio 1.09, 95% confidence interval 0.97 to 1.23, P=0.15). Neither L-arginine nor symmetric dimethylarginine was related to new-onset AF. A clinical model comprising clinical risk factors for AF (for age, sex, height, weight, systolic blood pressure, diastolic blood pressure, current smoking, diabetes, hypertension treatment, myocardial infarction, and heart failure) (C-statistic: 0.781; 95% confidence interval, 0.753 to 0.808) was not improved by the addition of ADMA (0.782; 95% confidence interval, 0.755 to 0.809). Conclusions: ADMA and related arginine derivatives were not associated with incident AF in the community after accounting for other clinical risk factors and confounders. Its role in the pathogenesis of AF needs further refinement. äAsymmetric Dimethylarginine, Related Arginine Derivatives and Incident(epmc).pdf DeepDyve Pubget Overpricing