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10.1038/srep27838 http://scihub22266oqcxt.onion/10.1038/srep27838 C4899798!4899798 !27278903     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=27278903 &cmd=llinks): Failed to open stream: HTTP request failed! 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Leptospiral outer membrane protein LipL32 induces inflammation and kidney injury in zebrafish larvae |pdf=|usr=}}{{27278903 }} gab.com Text Leptospiral outer membrane protein LipL32 induces inflammation and kidney injury in zebrafish larvae JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=27278903 #FOAvip Leptospirosis is an often overlooked cause of acute kidney injury that can lead to multiple organ failure and even death. The principle protein that conserved in many pathogenic leptospires is the outer membrane protein LipL32. However, the role of LipL32 in the pathogenesis of renal injury in leptospirosis is not entirely clear. Here we studied the effects of LipL32 on the developing kidney in zebrafish larvae. Incubation of zebrafish larvae with Leptospira santarosai serovar Shermani induced acute tubular injury predominantly in the proximal pronephric ducts. Furthermore, microinjection of lipl32 mRNA or recombinant LipL32 protein into zebrafish larvae increased macrophage accumulation and disrupted the basolateral location of NA-K-ATPase in pronephric ducts. These changes led to substantial impairment of the pronephric kidney structure. We further demonstrated that morpholino knockdown of tlr2, but not tlr4, reduced the LipL32-induced leukocyte infiltration and kidney injury. These data demonstrate that LipL32 contributes to the renal pathology in leptospirosis and gives some clues to the potential virulence of LipL32. Our results support the use of zebrafish as a model organism for studying the disease mechanism of leptospiral infection. This model might permit the future exploration of the virulence and molecular pathways of different leptospiral outer membrane proteins. Twit Text FOAVip Leptospiral outer membrane protein LipL32 induces inflammation and kidney injury in zebrafish larvae ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=27278903 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27278903 #FOAvip English Wikipedia <ref>{{Cite pmid|27278903 }}</ref> Leptospiral outer membrane protein LipL32 induces inflammation and kidney injury in zebrafish larvae #MMPMID27278903 Chang MY ; Cheng YC ; Hsu SH ; Ma TL ; Chou LF ; Hsu HH ; Tian YC ; Chen YC ; Sun YJ ; Hung CC ; Pan RL ; Yang CW Sci Rep 2016[Jun]; 6 (ä): 27838 PMID27278903 show ga Leptospirosis is an often overlooked cause of acute kidney injury that can lead to multiple organ failure and even death. The principle protein that conserved in many pathogenic leptospires is the outer membrane protein LipL32. However, the role of LipL32 in the pathogenesis of renal injury in leptospirosis is not entirely clear. Here we studied the effects of LipL32 on the developing kidney in zebrafish larvae. Incubation of zebrafish larvae with Leptospira santarosai serovar Shermani induced acute tubular injury predominantly in the proximal pronephric ducts. Furthermore, microinjection of lipl32 mRNA or recombinant LipL32 protein into zebrafish larvae increased macrophage accumulation and disrupted the basolateral location of NA-K-ATPase in pronephric ducts. These changes led to substantial impairment of the pronephric kidney structure. We further demonstrated that morpholino knockdown of tlr2, but not tlr4, reduced the LipL32-induced leukocyte infiltration and kidney injury. These data demonstrate that LipL32 contributes to the renal pathology in leptospirosis and gives some clues to the potential virulence of LipL32. Our results support the use of zebrafish as a model organism for studying the disease mechanism of leptospiral infection. This model might permit the future exploration of the virulence and molecular pathways of different leptospiral outer membrane proteins. |*Kidney Diseases/embryology/genetics/microbiology [MESH] |*Kidney/embryology/microbiology [MESH] |*Pronephros/embryology/microbiology [MESH] |*Zebrafish/embryology/microbiology [MESH] |Animals [MESH] |Bacterial Outer Membrane Proteins/genetics/*metabolism [MESH] |Inflammation/embryology/genetics/microbiology [MESH] |Leptospira/genetics/*metabolism [MESH]Leptospiral outer membrane protein LipL32 induces inflammation and kid(epmc).pdf DeepDyve Pubget Overpricing