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10.1038/srep27769 http://scihub22266oqcxt.onion/10.1038/srep27769 C4899795!4899795!27277011     free     free     free Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Sci+Rep 2016 ; 6 (ä): ä Nephropedia Template TP {{tp|p=27277011|t=2016. Maternal Obesity Promotes Diabetic Nephropathy in Rodent Offspring |pdf=|usr=}}{{27277011}} gab.com Text Maternal Obesity Promotes Diabetic Nephropathy in Rodent Offspring JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=27277011 #FOAvip Maternal obesity is known to increase the risk of obesity and diabetes in offspring. Though diabetes is a key risk factor for the development of chronic kidney disease (CKD), the relationship between maternal obesity and CKD has not been clearly defined. In this study, a mouse model of maternal obesity was employed to determine the impact of maternal obesity on development of diabetic nephropathy in offspring. Female C57BL/6 mice were fed high-fat diet (HFD) for six weeks prior to mating, during gestation and lactation. Male offspring were weaned to normal chow diet. At postnatal Week 8, offspring were randomly administered low dose streptozotocin (STZ, 55?mg/kg/day for five days) to induce diabetes. Assessment of renal damage took place at postnatal Week 32. We found that offspring of obese mothers had increased renal fibrosis, inflammation and oxidative stress. Importantly, offspring exposed to maternal obesity had increased susceptibility to renal damage when an additional insult, such as STZ-induced diabetes, was imposed. Specifically, renal inflammation and oxidative stress induced by diabetes was augmented by maternal obesity. Our findings suggest that developmental programming induced by maternal obesity has implications for renal health in offspring. Maternal obesity should be considered a risk factor for CKD. Twit Text FOAVip Maternal Obesity Promotes Diabetic Nephropathy in Rodent Offspring ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=27277011 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27277011 #FOAvip English Wikipedia <ref>{{Cite pmid|27277011}}</ref> Maternal Obesity Promotes Diabetic Nephropathy in Rodent Offspring #MMPMID27277011 Glastras SJ; Tsang M; Teh R; Chen H; McGrath RT; Zaky AA; Pollock CA; Saad S Sci Rep 2016[]; 6 (ä): ä PMID27277011show ga Maternal obesity is known to increase the risk of obesity and diabetes in offspring. Though diabetes is a key risk factor for the development of chronic kidney disease (CKD), the relationship between maternal obesity and CKD has not been clearly defined. In this study, a mouse model of maternal obesity was employed to determine the impact of maternal obesity on development of diabetic nephropathy in offspring. Female C57BL/6 mice were fed high-fat diet (HFD) for six weeks prior to mating, during gestation and lactation. Male offspring were weaned to normal chow diet. At postnatal Week 8, offspring were randomly administered low dose streptozotocin (STZ, 55?mg/kg/day for five days) to induce diabetes. Assessment of renal damage took place at postnatal Week 32. We found that offspring of obese mothers had increased renal fibrosis, inflammation and oxidative stress. Importantly, offspring exposed to maternal obesity had increased susceptibility to renal damage when an additional insult, such as STZ-induced diabetes, was imposed. Specifically, renal inflammation and oxidative stress induced by diabetes was augmented by maternal obesity. Our findings suggest that developmental programming induced by maternal obesity has implications for renal health in offspring. Maternal obesity should be considered a risk factor for CKD. äMaternal Obesity Promotes Diabetic Nephropathy in Rodent Offspring (epmc).pdf DeepDyve Pubget Overpricing