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10.1038/srep27623 http://scihub22266oqcxt.onion/10.1038/srep27623 C4899742!4899742 !27279139     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=27279139 &cmd=llinks): Failed to open stream: HTTP request failed! 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Multiplex giant magnetoresistive biosensor microarrays identify interferon-associated autoantibodies in systemic lupus erythematosus |pdf=|usr=}}{{27279139 }} gab.com Text Multiplex giant magnetoresistive biosensor microarrays identify interferon-associated autoantibodies in systemic lupus erythematosus JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=27279139 #FOAvip High titer, class-switched autoantibodies are a hallmark of systemic lupus erythematosus (SLE). Dysregulation of the interferon (IFN) pathway is observed in individuals with active SLE, although the association of specific autoantibodies with chemokine score, a combined measurement of three IFN-regulated chemokines, is not known. To identify autoantibodies associated with chemokine score, we developed giant magnetoresistive (GMR) biosensor microarrays, which allow the parallel measurement of multiple serum antibodies to autoantigens and peptides. We used the microarrays to analyze serum samples from SLE patients and found individuals with high chemokine scores had significantly greater reactivity to 13 autoantigens than individuals with low chemokine scores. Our findings demonstrate that multiple autoantibodies, including antibodies to U1-70K and modified histone H2B tails, are associated with IFN dysregulation in SLE. Further, they show the microarrays are capable of identifying autoantibodies associated with relevant clinical manifestations of SLE, with potential for use as biomarkers in clinical practice. Twit Text FOAVip Multiplex giant magnetoresistive biosensor microarrays identify interferon-associated autoantibodies in systemic lupus erythematosus ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=27279139 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27279139 #FOAvip English Wikipedia <ref>{{Cite pmid|27279139 }}</ref> Multiplex giant magnetoresistive biosensor microarrays identify interferon-associated autoantibodies in systemic lupus erythematosus #MMPMID27279139 Lee JR ; Haddon DJ ; Wand HE ; Price JV ; Diep VK ; Hall DA ; Petri M ; Baechler EC ; Balboni IM ; Utz PJ ; Wang SX Sci Rep 2016[Jun]; 6 (ä): 27623 PMID27279139 show ga High titer, class-switched autoantibodies are a hallmark of systemic lupus erythematosus (SLE). Dysregulation of the interferon (IFN) pathway is observed in individuals with active SLE, although the association of specific autoantibodies with chemokine score, a combined measurement of three IFN-regulated chemokines, is not known. To identify autoantibodies associated with chemokine score, we developed giant magnetoresistive (GMR) biosensor microarrays, which allow the parallel measurement of multiple serum antibodies to autoantigens and peptides. We used the microarrays to analyze serum samples from SLE patients and found individuals with high chemokine scores had significantly greater reactivity to 13 autoantigens than individuals with low chemokine scores. Our findings demonstrate that multiple autoantibodies, including antibodies to U1-70K and modified histone H2B tails, are associated with IFN dysregulation in SLE. Further, they show the microarrays are capable of identifying autoantibodies associated with relevant clinical manifestations of SLE, with potential for use as biomarkers in clinical practice. |Autoantibodies/*blood/immunology [MESH] |Biosensing Techniques/*methods [MESH] |Case-Control Studies [MESH] |Humans [MESH] |Immunoassay/*methods [MESH] |Interferons/*immunology [MESH] |Lupus Erythematosus, Systemic/*blood [MESH] |Molecular Diagnostic Techniques/*methods [MESH] |Protein Array Analysis/*methods [MESH] |Ribonucleoprotein, U1 Small Nuclear/immunology [MESH]Multiplex giant magnetoresistive biosensor microarrays identify inte(epmc).pdf DeepDyve Pubget Overpricing