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10.1016/j.cytogfr.2016.03.008 http://scihub22266oqcxt.onion/10.1016/j.cytogfr.2016.03.008 C4899287!4899287!27068414     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=27068414&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cytokine+Growth+Factor+Rev 2016 ; 29 (ä): 17-22 Nephropedia Template TP {{tp|p=27068414|t=2016. Beyond autophagy: New roles for ULK1 in immune signaling and interferon responses |pdf=|usr=}}{{27068414}} gab.com Text Beyond autophagy: New roles for ULK1 in immune signaling and interferon responses JO: Cytokine Growth Factor Rev http://www.kidney.de/pget.php?&tw=1&pmid=27068414 #FOAvip The human serine/threonine kinase ULK1 is the human homolog of the Caenorhabditis elegans Unc-51 kinase and of the Saccharomyces cerevisiae autophagy-related protein kinase Atg1. As Unc-51 and Atg1, ULK1 regulates both axon growth and autophagy, respectively, in mammalian cells. However, a novel immunoregulatory role of ULK1 has been recently described. This kinase was shown to be required for regulation of both type I interferon (IFN) production and induction of type I IFN signaling. Optimal regulation of IFN production is crucial for generation of effective IFN-immune responses, and defects in such networks can be detrimental for the host leading to uncontrolled pathogen infection, tumor growth, or autoimmune diseases. Thus, ULK1 plays a central role in IFN-dependent immunity. Here we review the diverse roles of ULK1, with special focus on its importance to type I IFN signaling, and highlight important future study questions. Twit Text FOAVip Beyond autophagy: New roles for ULK1 in immune signaling and interferon responses ????Cytokine Growth Factor Rev http://www.kidney.de/pget.php?&tw=1&pmid=27068414 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27068414 #FOAvip English Wikipedia <ref>{{Cite pmid|27068414}}</ref> Beyond autophagy: New roles for ULK1 in immune signaling and interferon responses #MMPMID27068414 Saleiro D; Kosciuczuk EM; Platanias LC Cytokine Growth Factor Rev 2016[Jun]; 29 (ä): 17-22 PMID27068414show ga The human serine/threonine kinase ULK1 is the human homolog of the Caenorhabditis elegans Unc-51 kinase and of the Saccharomyces cerevisiae autophagy-related protein kinase Atg1. As Unc-51 and Atg1, ULK1 regulates both axon growth and autophagy, respectively, in mammalian cells. However, a novel immunoregulatory role of ULK1 has been recently described. This kinase was shown to be required for regulation of both type I interferon (IFN) production and induction of type I IFN signaling. Optimal regulation of IFN production is crucial for generation of effective IFN-immune responses, and defects in such networks can be detrimental for the host leading to uncontrolled pathogen infection, tumor growth, or autoimmune diseases. Thus, ULK1 plays a central role in IFN-dependent immunity. Here we review the diverse roles of ULK1, with special focus on its importance to type I IFN signaling, and highlight important future study questions. äBeyond autophagy: New roles for ULK1 in immune signaling and interfero(epmc).pdf DeepDyve Pubget Overpricing