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10.1016/j.celrep.2016.04.087 http://scihub22266oqcxt.onion/10.1016/j.celrep.2016.04.087 C4899175!4899175!27239026     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cell+Rep 2016 ; 15 (10): 2159-69 Nephropedia Template TP {{tp|p=27239026|t=2016. Active and inactive enhancers co-operate to exert localized and long-range control of gene regulation |pdf=|usr=}}{{27239026}} gab.com Text Active and inactive enhancers co-operate to exert localized and long-range control of gene regulation JO: Cell Rep http://www.kidney.de/pget.php?&tw=1&pmid=27239026 #FOAvip V(D)J recombination relies on the presence of proximal enhancers that activate the antigen receptor (AgR) loci in a lineage and stage specific manner. Unexpectedly we find that both active and inactive AgR enhancers co-operate to disseminate their effects in a localized and long-range manner. Here we demonstrate the importance of short-range contacts between active enhancers that constitute an Igk super-enhancer in B cells. Deletion of one element reduces the interaction frequency between other enhancers in the hub, which compromises the transcriptional output of each component. We further establish that in T cells long-range contact and co-operation between the inactive Igk enhancer, MiE? and the active Tcrb enhancer, E?, alters enrichment of CBF? binding in a manner that impacts Tcrb recombination. These findings underline the complexities of enhancer regulation and point to a role for localized and long-range enhancer-sharing between active and inactive elements in lineage and stage specific control. Twit Text FOAVip Active and inactive enhancers co-operate to exert localized and long-range control of gene regulation ????Cell Rep http://www.kidney.de/pget.php?&tw=1&pmid=27239026 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27239026 #FOAvip English Wikipedia <ref>{{Cite pmid|27239026}}</ref> Active and inactive enhancers co-operate to exert localized and long-range control of gene regulation #MMPMID27239026 Proudhon C; Snetkova V; Raviram R; Lobry C; Badri S; Jiang T; Hao B; Trimarchi T; Kluger Y; Aifantis I; Bonneau R; Skok JA Cell Rep 2016[Jun]; 15 (10): 2159-69 PMID27239026show ga V(D)J recombination relies on the presence of proximal enhancers that activate the antigen receptor (AgR) loci in a lineage and stage specific manner. Unexpectedly we find that both active and inactive AgR enhancers co-operate to disseminate their effects in a localized and long-range manner. Here we demonstrate the importance of short-range contacts between active enhancers that constitute an Igk super-enhancer in B cells. Deletion of one element reduces the interaction frequency between other enhancers in the hub, which compromises the transcriptional output of each component. We further establish that in T cells long-range contact and co-operation between the inactive Igk enhancer, MiE? and the active Tcrb enhancer, E?, alters enrichment of CBF? binding in a manner that impacts Tcrb recombination. These findings underline the complexities of enhancer regulation and point to a role for localized and long-range enhancer-sharing between active and inactive elements in lineage and stage specific control. äActive and inactive enhancers co-operate to exert localized and long-r(epmc).pdf DeepDyve Pubget Overpricing