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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Exp+Mol+Pathol
2016 ; 100
(3
): 426-33
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
The mechanisms of Mallory-Denk body formation are similar to the formation of
aggresomes in Alzheimer s disease and other neurodegenerative disorders
#MMPMID27068270
French SW
; Mendoza AS
; Peng Y
Exp Mol Pathol
2016[Jun]; 100
(3
): 426-33
PMID27068270
show ga
There is a possibility that the aggresomes that form in the brain in
neurodegenerative diseases like Alzheimer's disease (AD) and in the liver where
aggresomes like Mallory-Denk Bodies (MDB) form, share mechanisms. MDBs can be
prevented by feeding mice sadenosylmethionine (SAMe) or betaine. Possibly these
proteins could prevent AD. We compared the literature on MDBs and AD
pathogenesis, which include roles played by p62, ubiquitin UBB +1, HSPs70, 90,
104, FAT10, NEDD8, VCP/97, and the protein quality control mechanisms including
the 26s proteasome, the IPOD and JUNQ and autophagosome pathways.