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10.1111/nyas.12989

http://scihub22266oqcxt.onion/10.1111/nyas.12989
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C4899120!4899120!26748878
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suck abstract from ncbi


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pmid26748878      Ann+N+Y+Acad+Sci 2016 ; 1370 (1): 24-35
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  • Converting cell fates: generating hematopoietic stem cells de novo via transcription factor reprogramming #MMPMID26748878
  • Daniel MG; Lemischka IR; Moore K
  • Ann N Y Acad Sci 2016[Apr]; 1370 (1): 24-35 PMID26748878show ga
  • Even though all paradigms of stem cell therapy and regenerative medicine emerged from the study of hematopoietic stem cells (HSCs), our inability to generate these cells de novo or expand them in vitro persists. Initial efforts to obtain these cells began with the use of embryonic stem cell (ESC) and induced pluripotent stem cell (iPSC) technologies, but these strategies have yet to yield fully functional cells. Subsequently, more recent approaches involve transcription factor (TF) overexpression to reprogram PSCs and various somatic cells. The induction of pluripotency with just four TFs by Shinya Yamanaka informs our ability to convert cell fates, and demonstrates the feasibility of utilizing terminally differentiated cells to generate cells with multilineage potential. In this review, we discuss the recent efforts undertaken using TF-based reprogramming strategies to convert several cell types into HSCs.
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