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10.1530/JME-15-0323 http://scihub22266oqcxt.onion/10.1530/JME-15-0323 C4899099!4899099!26880796     free     free     free Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Mol+Endocrinol 2016 ; 56 (4): T77-97 Nephropedia Template TP {{tp|p=26880796|t=2016. Biosynthesis, Trafficking and Secretion of Pro-opiomelanocortin-derived peptides |pdf=|usr=}}{{26880796}} gab.com Text Biosynthesis, Trafficking and Secretion of Pro-opiomelanocortin-derived peptides JO: J Mol Endocrinol http://www.kidney.de/pget.php?&tw=1&pmid=26880796 #FOAvip Pro-opiomelanocortin (POMC) is a prohormone that encodes multiple smaller peptide hormones within its structure. These peptide hormones can be generated by cleavage of POMC at basic-residue cleavage sites by prohormone converting enzymes in the regulated secretory pathway of POMC synthesizing endocrine cells and neurons. The peptides are stored inside the cells in dense core secretory granules until released in a stimulus dependent manner. The complexity of the regulation of the biosynthesis, trafficking and secretion of POMC and its peptides reflect an impressive level of control over many factors involved in the ultimate role of POMC expressing cells, i.e. to produce a range of different biologically active peptide hormones ready for action when signaled by the body. From the discovery of POMC as the precursor to ACTH and ?-Lipotropin in the late 1970s to our current knowledge, the understanding of POMC physiology remains a monumental body of work that has provided insight into many aspects of molecular endocrinology. In this chapter, we describe the intracellular trafficking of POMC in endocrine cells, its sorting into dense core secretory granules and transport of these granules to the regulated secretory pathway. Additionally, we review the enzymes involved in the maturation of POMC to its various peptides and the mechanisms involved in the differential processing of POMC in different cell types. Finally, we highlight studies pertaining to the regulation of ACTH secretion in the anterior and intermediate pituitary and POMC neurons of the hypothalamus. Twit Text FOAVip Biosynthesis, Trafficking and Secretion of Pro-opiomelanocortin-derived peptides ????J Mol Endocrinol http://www.kidney.de/pget.php?&tw=1&pmid=26880796 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26880796 #FOAvip English Wikipedia <ref>{{Cite pmid|26880796}}</ref> Biosynthesis, Trafficking and Secretion of Pro-opiomelanocortin-derived peptides #MMPMID26880796 Cawley NX; Li Z; Loh YP J Mol Endocrinol 2016[May]; 56 (4): T77-97 PMID26880796show ga Pro-opiomelanocortin (POMC) is a prohormone that encodes multiple smaller peptide hormones within its structure. These peptide hormones can be generated by cleavage of POMC at basic-residue cleavage sites by prohormone converting enzymes in the regulated secretory pathway of POMC synthesizing endocrine cells and neurons. The peptides are stored inside the cells in dense core secretory granules until released in a stimulus dependent manner. The complexity of the regulation of the biosynthesis, trafficking and secretion of POMC and its peptides reflect an impressive level of control over many factors involved in the ultimate role of POMC expressing cells, i.e. to produce a range of different biologically active peptide hormones ready for action when signaled by the body. From the discovery of POMC as the precursor to ACTH and ?-Lipotropin in the late 1970s to our current knowledge, the understanding of POMC physiology remains a monumental body of work that has provided insight into many aspects of molecular endocrinology. In this chapter, we describe the intracellular trafficking of POMC in endocrine cells, its sorting into dense core secretory granules and transport of these granules to the regulated secretory pathway. Additionally, we review the enzymes involved in the maturation of POMC to its various peptides and the mechanisms involved in the differential processing of POMC in different cell types. Finally, we highlight studies pertaining to the regulation of ACTH secretion in the anterior and intermediate pituitary and POMC neurons of the hypothalamus. äBiosynthesis, Trafficking and Secretion of Pro-opiomelanocortin-derive(epmc).pdf DeepDyve Pubget Overpricing