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10.1111/ejn.13239

http://scihub22266oqcxt.onion/10.1111/ejn.13239
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C4899089!4899089!26991018
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suck abstract from ncbi


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pmid26991018      Eur+J+Neurosci 2016 ; 43 (11): 1431-9
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  • The ventromedial hypothalamus mediates predator fear memory #MMPMID26991018
  • Silva BA; Mattucci C; Kryzwkowski P; Cuozzo R; Carbonari L; Gross CT
  • Eur J Neurosci 2016[Jun]; 43 (11): 1431-9 PMID26991018show ga
  • The amygdala has been shown to be essential for the processing of acute and learned fear across animal species. However, the downstream neural circuits that mediate these fear responses differ depending on the nature of the threat, with separate pathways identified for predator, conspecific, and physically harmful threats. In particular, the dorsomedial part of the ventromedial hypothalamus (VHMdm) is critical for the expression of defensive responses to predator. Here, we tested the hypothesis that this circuit also participates in predator fear memory by transient pharmacogenetic inhibition of VMHdm and its downstream effector, the dorsal periaqueductal grey, during predator fear learning in the mouse. Our data demonstrate that neural activity in VMHdm is required for both the acquisition and recall of predator fear memory, while that of its downstream effector, the dorsal periaqueductal grey, is required only for the acute expression of fear. These findings are consistent with a role for the medial hypothalamus in encoding an internal emotional state of fear.
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