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10.3892/ijmm.2016.2616 http://scihub22266oqcxt.onion/10.3892/ijmm.2016.2616 C4899020!4899020 !27247107     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\27247107 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Int+J+Mol+Med 2016 ; 38 (1 ): 210-6 Nephropedia Template TP {{tp|p=27247107 |t=2016. Brazilin exerts protective effects against renal ischemia-reperfusion injury by inhibiting the NF-?B signaling pathway |pdf=|usr=}}{{27247107 }} gab.com Text Brazilin exerts protective effects against renal ischemia-reperfusion injury by inhibiting the NF- B signaling pathway JO: Int J Mol Med http://www.kidney.de/pget.php?&tw=1&pmid=27247107 #FOAvip Renal ischemia-reperfusion (I/R) injury is associated with high morbidity and mortality as there is currently no available effective therapeutic strategy with which to treat this injury. Thus, the aim of this study was to investigate the potential protective effects of brazilin, a major active component of the Chinese medicine Caesalpinia sappan L., against renal I/R injury in vitro and in vivo. Rats were subjected to removal of the right kidney and I/R injury to the left kidney (ischemia for 45 min followed by reperfusion for 24 h). Treatment with brazilin (30 mg/kg, administered intravenously at 30 min prior to ischemia) led to the reversal of I/R-induced changes in serum creatinine (Scr) and blood urea nitrogen (BUN) levels, and also attenuated the histopathological damage induced by I/R. Furthermore, TUNEL assay revealed that brazilin reduced cell necrosis, and significantly decreased the expression of tumor necrosis factor (TNF)-? and interleukin (IL)-1? in renal tissue. Moreover, HK-2 cells were used in order to elucidate the mechanisms responsible for the protective effects of brazilin. The levels of phosphorylated I?B? and the nuclear translocation of nuclear factor-?B (NF-?B) were all evidently decreased by brazilin. These findings suggested that pre-treatment with brazilin protects against I/R-induced renal damage and suppresses the inflammatory response by inhibiting the activation of the NF-?B signaling pathway. Twit Text FOAVip Brazilin exerts protective effects against renal ischemia-reperfusion injury by inhibiting the NF- B signaling pathway ????Int J Mol Med http://www.kidney.de/pget.php?&tw=1&pmid=27247107 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27247107 #FOAvip English Wikipedia <ref>{{Cite pmid|27247107 }}</ref> Brazilin exerts protective effects against renal ischemia-reperfusion injury by inhibiting the NF-?B signaling pathway #MMPMID27247107 Jia Y ; Zhao J ; Liu M ; Li B ; Song Y ; Li Y ; Wen A ; Shi L Int J Mol Med 2016[Jul]; 38 (1 ): 210-6 PMID27247107 show ga Renal ischemia-reperfusion (I/R) injury is associated with high morbidity and mortality as there is currently no available effective therapeutic strategy with which to treat this injury. Thus, the aim of this study was to investigate the potential protective effects of brazilin, a major active component of the Chinese medicine Caesalpinia sappan L., against renal I/R injury in vitro and in vivo. Rats were subjected to removal of the right kidney and I/R injury to the left kidney (ischemia for 45 min followed by reperfusion for 24 h). Treatment with brazilin (30 mg/kg, administered intravenously at 30 min prior to ischemia) led to the reversal of I/R-induced changes in serum creatinine (Scr) and blood urea nitrogen (BUN) levels, and also attenuated the histopathological damage induced by I/R. Furthermore, TUNEL assay revealed that brazilin reduced cell necrosis, and significantly decreased the expression of tumor necrosis factor (TNF)-? and interleukin (IL)-1? in renal tissue. Moreover, HK-2 cells were used in order to elucidate the mechanisms responsible for the protective effects of brazilin. The levels of phosphorylated I?B? and the nuclear translocation of nuclear factor-?B (NF-?B) were all evidently decreased by brazilin. These findings suggested that pre-treatment with brazilin protects against I/R-induced renal damage and suppresses the inflammatory response by inhibiting the activation of the NF-?B signaling pathway. |*Signal Transduction/drug effects [MESH] |Animals [MESH] |Apoptosis/drug effects [MESH] |Benzopyrans/chemistry/pharmacology/*therapeutic use [MESH] |Humans [MESH] |Inflammation/pathology [MESH] |Ischemic Preconditioning [MESH] |Kidney Tubules/drug effects/pathology [MESH] |Kidney/*blood supply/drug effects/pathology [MESH] |Male [MESH] |NF-kappa B/*metabolism [MESH] |Protective Agents/chemistry/pharmacology/*therapeutic use [MESH] |Rats, Sprague-Dawley [MESH]Brazilin exerts protective effects against renal ischemia-reperfusion (epmc).pdf DeepDyve Pubget Overpricing