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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 J+Allergy+Clin+Immunol
2016 ; 137
(6
): 1631-1645
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Fifty years later: Emerging functions of IgE antibodies in host defense, immune
regulation, and allergic diseases
#MMPMID27263999
Oettgen HC
J Allergy Clin Immunol
2016[Jun]; 137
(6
): 1631-1645
PMID27263999
show ga
Fifty years ago, after a long search, IgE emerged as the circulating factor
responsible for triggering allergic reactions. Its extremely low concentration in
plasma created significant hurdles for scientists working to reveal its identity.
We now know that IgE levels are invariably increased in patients affected by
atopic conditions and that IgE provides the critical link between the antigen
recognition role of the adaptive immune system and the effector functions of mast
cells and basophils at mucosal and cutaneous sites of environmental exposure.
This review discusses the established mechanisms of action of IgE in pathologic
immediate hypersensitivity, as well as its multifaceted roles in protective
immunity, control of mast cell homeostasis, and its more recently revealed
immunomodulatory functions.