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2016 ; 9
(2
): 47-54
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Chronic Hepatitis C Virus Infection: A Review of Current Direct-Acting Antiviral
Treatment Strategies
#MMPMID27293521
Zhang J
; Nguyen D
; Hu KQ
N Am J Med Sci (Boston)
2016[Apr]; 9
(2
): 47-54
PMID27293521
show ga
Chronic Hepatitis C virus (HCV) infection carries a significant clinical burden
in the United States, affecting more than 4.6 million Americans. Untreated
chronic HCV infection can result in cirrhosis, portal hypertension, and
hepatocellular carcinoma. Previous interferon based treatment carried low rates
of success and significant adverse effects. The advent of new generation oral
antiviral therapy has led to major improvements in efficacy and tolerability but
has also resulted in an explosion of data with increased treatment choice
complexity. Treatment guidelines are constantly evolving due to emerging regimens
and real world treatment data. There also still remain subpopulations for whom
current treatments are lacking or unclearly defined. Thus, the race for
development of HCV treatment regimens still continues. This review of the current
literature will discuss the current recommended treatment strategies and briefly
overview next generation agents.