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2014 ; 2014
(ä): 275194
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The Usefulness of Endothelial Cell Adhesion Molecules and Anti-C1q Antibody in
Monitoring Systemic Lupus Erythematosus Disease Activity
#MMPMID27355017
Mahayidin H
; Yahya NK
; Wan Ghazali WS
; Mohd Ismail A
; Wan Ab Hamid WZ
Int Sch Res Notices
2014[]; 2014
(ä): 275194
PMID27355017
show ga
Objectives. The study was conducted to determine the correlation of ICAM-1,
VCAM-1, and anti-C1q antibody levels with SLE disease activity index (SLEDAI) and
standard SLE disease activity immunological markers (anti-dsDNA and sera C3 and
C4). Study Design. This was a cross-sectional study. Materials and Methods. Blood
samples were obtained from 95 SLE patients (45 active SLE and 50 nonactive SLE)
and 50 controls. The subjects were assessed using SLEDAI and score of more than
five is determined as having active SLE. The sera were tested for serum ICAM-1,
VCAM-1, and anti-C1q (ELISA), anti-dsDNA (CLIFT), serum C3, and serum C4
(immunonephelometry). Results. Anti-dsDNA and anti-C1q antibody showed good
positive correlations with SLEDAI (r = 0.529, P < 0.001 and r = 0.559, P < 0.001,
resp.). VCAM-1 and sera C3 and C4 showed fair correlation with SLEDAI (r = 0.294,
P = 0.004; r = -0.312, P = 0.002; and r = -0.382, P < 0.001, resp.). ICAM-1 level
showed no significant correlation with SLEDAI (P = 0.062). There were significant
correlations of VCAM-1 and anti-C1q antibody with anti-dsDNA (r = 0.226, P =
0.006 and r = 0.511, P < 0.001, resp.). VCAM-1 showed poor inverse correlation
with serum C3 (r = -0.183, P = 0.028) and fair inverse correlation with serum C4
(r = -0.251, P = 0.002). Anti-C1q antibody demonstrated fair inverse correlation
with both sera C3 and C4 (r = -0.420, P ? 0.001 and r = -0.398, P < 0.001,
resp.). However, ICAM-1 showed no significant correlation with anti-dsDNA and
sera C3 and C4 (P = 0.259, P = 0.626 and P = 0.338, resp.). Conclusions. The
serum levels of anti-C1q antibody in SLE patients showed the best correlation
with the SLEDAI and standard immunological tests for SLE disease activity. These
data support that anti-C1q antibody is a useful marker for monitoring SLE global
disease activity. The potential of VCAM-1 needs further confirmation.