MYC ? a thorn in the side of cancer immunity #MMPMID27113275
Spranger S; Gajewski TF; Kline J
Cell Res 2016[Jun]; 26 (6): 639-40 PMID27113275show ga
For decades, MYC has been known for its role in regulating cancer cell proliferation and survival. In a recent paper published in Science, Casey et al. have uncovered a new function for MYC in promoting immune evasion by directly regulating expression of programmed death-ligand 1 (PD-L1) and CD47 on cancer cells.