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10.4161/hv.29520 http://scihub22266oqcxt.onion/10.4161/hv.29520 C4896785!4896785 !25424939     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\25424939 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Hum+Vaccin+Immunother 2014 ; 10 (8 ): 2328-35 Nephropedia Template TP {{tp|p=25424939 |t=2014. Thimerosal compromises human dendritic cell maturation, IL-12 production, chemokine release, and T-helper polarization |pdf=|usr=}}{{25424939 }} gab.com Text Thimerosal compromises human dendritic cell maturation, IL-12 production, chemokine release, and T-helper polarization JO: Hum Vaccin Immunother http://www.kidney.de/pget.php?&tw=1&pmid=25424939 #FOAvip Thimerosal is a preservative used in multidose vials of vaccine formulations to prevent bacterial and fungal contamination. We recently reported that nanomolar concentrations of thimerosal induce cell cycle arrest of human T cells activated via the TCR and inhibition of proinflammatory cytokine production, thus interfering with T-cell functions. Given the essential role of dendritic cells (DCs) in T-cell polarization and vaccine immunity, we studied the influence of non-toxic concentrations of thimerosal on DC maturation and functions. Ex-vivo exposure of human monocyte-derived DCs to nanomolar concentrations of thimerosal prevented LPS-induced DC maturation, as evidenced by the inhibition of morphological changes and a decreased expression of the maturation markers CD86 and HLA-DR. In addition thimerosal dampened their proinflammatory response, in particular the production of the Th1 polarizing cytokine IL-12, as well as TNF-? and IL-6. DC-dependent T helper polarization was altered, leading to a decreased production of IFN-? IP10 and GM-CSF and increased levels of IL-8, IL-9, and MIP-1?. Although multi-dose vials of vaccines containing thimerosal remain important for vaccine delivery, our results alert about the ex-vivo immunomodulatory effects of thimerosal on DCs, a key player for the induction of an adaptive response. Twit Text FOAVip Thimerosal compromises human dendritic cell maturation, IL-12 production, chemokine release, and T-helper polarization ????Hum Vaccin Immunother http://www.kidney.de/pget.php?&tw=1&pmid=25424939 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25424939 #FOAvip English Wikipedia <ref>{{Cite pmid|25424939 }}</ref> Thimerosal compromises human dendritic cell maturation, IL-12 production, chemokine release, and T-helper polarization #MMPMID25424939 Loison E ; Gougeon ML Hum Vaccin Immunother 2014[]; 10 (8 ): 2328-35 PMID25424939 show ga Thimerosal is a preservative used in multidose vials of vaccine formulations to prevent bacterial and fungal contamination. We recently reported that nanomolar concentrations of thimerosal induce cell cycle arrest of human T cells activated via the TCR and inhibition of proinflammatory cytokine production, thus interfering with T-cell functions. Given the essential role of dendritic cells (DCs) in T-cell polarization and vaccine immunity, we studied the influence of non-toxic concentrations of thimerosal on DC maturation and functions. Ex-vivo exposure of human monocyte-derived DCs to nanomolar concentrations of thimerosal prevented LPS-induced DC maturation, as evidenced by the inhibition of morphological changes and a decreased expression of the maturation markers CD86 and HLA-DR. In addition thimerosal dampened their proinflammatory response, in particular the production of the Th1 polarizing cytokine IL-12, as well as TNF-? and IL-6. DC-dependent T helper polarization was altered, leading to a decreased production of IFN-? IP10 and GM-CSF and increased levels of IL-8, IL-9, and MIP-1?. Although multi-dose vials of vaccines containing thimerosal remain important for vaccine delivery, our results alert about the ex-vivo immunomodulatory effects of thimerosal on DCs, a key player for the induction of an adaptive response. |Adult [MESH] |Cell Differentiation/*drug effects [MESH] |Cells, Cultured [MESH] |Chemokines/metabolism [MESH] |Dendritic Cells/*drug effects/physiology [MESH] |Humans [MESH] |Immunologic Factors/*metabolism [MESH] |Interleukin-12/*metabolism [MESH] |Preservatives, Pharmaceutical/*metabolism [MESH] |T-Lymphocytes, Helper-Inducer/*immunology [MESH]Thimerosal compromises human dendritic cell maturation, IL-12 producti(epmc).pdf DeepDyve Pubget Overpricing