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10.1073/pnas.1603488113 http://scihub22266oqcxt.onion/10.1073/pnas.1603488113 C4896678!4896678 !27185953     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\27185953 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Proc+Natl+Acad+Sci+U+S+A 2016 ; 113 (22 ): 6212-7 Nephropedia Template TP {{tp|p=27185953 |t=2016. Structural characterization of the ternary complex that mediates termination of NF-?B signaling by I?B? |pdf=|usr=}}{{27185953 }} gab.com Text Structural characterization of the ternary complex that mediates termination of NF- B signaling by I B JO: Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=27185953 #FOAvip The transcription factor NF-?B is used in many systems for the transduction of extracellular signals into the expression of signal-responsive genes. Published structural data explain the activation of NF-?B through degradation of its dedicated inhibitor I?B?, but the mechanism by which NF-?B-mediated signaling is turned off by its removal from the DNA in the presence of newly synthesized I?B? (termed stripping) is unknown. Previous kinetic studies showed that I?B? accelerates NF-?B dissociation from DNA, and a transient ternary complex between NF-?B, its cognate DNA sequence, and I?B? was observed. Here we structurally characterize the >100-kDa ternary complex by NMR and negative stain EM and show a modeled structure that is consistent with the measurements. These data provide a structural basis for previously unidentified insights into the molecular mechanism of stripping. Twit Text FOAVip Structural characterization of the ternary complex that mediates termination of NF- B signaling by I B ????Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=27185953 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27185953 #FOAvip English Wikipedia <ref>{{Cite pmid|27185953 }}</ref> Structural characterization of the ternary complex that mediates termination of NF-?B signaling by I?B? #MMPMID27185953 Mukherjee SP ; Quintas PO ; McNulty R ; Komives EA ; Dyson HJ Proc Natl Acad Sci U S A 2016[May]; 113 (22 ): 6212-7 PMID27185953 show ga The transcription factor NF-?B is used in many systems for the transduction of extracellular signals into the expression of signal-responsive genes. Published structural data explain the activation of NF-?B through degradation of its dedicated inhibitor I?B?, but the mechanism by which NF-?B-mediated signaling is turned off by its removal from the DNA in the presence of newly synthesized I?B? (termed stripping) is unknown. Previous kinetic studies showed that I?B? accelerates NF-?B dissociation from DNA, and a transient ternary complex between NF-?B, its cognate DNA sequence, and I?B? was observed. Here we structurally characterize the >100-kDa ternary complex by NMR and negative stain EM and show a modeled structure that is consistent with the measurements. These data provide a structural basis for previously unidentified insights into the molecular mechanism of stripping. |*Signal Transduction [MESH] |*Transcription, Genetic [MESH] |DNA/*chemistry [MESH] |Humans [MESH] |Microscopy, Electron [MESH] |Models, Molecular [MESH] |NF-KappaB Inhibitor alpha/*chemistry [MESH] |NF-kappa B/*chemistry [MESH] |Nuclear Magnetic Resonance, Biomolecular [MESH]Structural characterization of the ternary complex that mediates termi(epmc).pdf DeepDyve Pubget Overpricing