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Asymptomatic memory CD8+ T cells: From development and regulation to consideration for human vaccines and immunotherapeutics #MMPMID24499824
Khan AA; Srivastava R; Lopes PP; Wang C; Pham TT; Cochrane J; Thai NTU; Gutierrez L; BenMohamed L
Hum Vaccin Immunother 2014[Apr]; 10 (4): 945-63 PMID24499824show ga
Generation and maintenance of high quantity and quality memory CD8+ T cells determine the level of protection from viral, bacterial, and parasitic re-infections, and hence constitutes a primary goal for T cell epitope-based human vaccines and immunotherapeutics. Phenotypically and functionally characterizing memory CD8+ T cells that provide protection against herpes simplex virus type 1 and type 2 (HSV-1 and HSV-2) infections, which cause blinding ocular herpes, genital herpes, and oro-facial herpes, is critical for better vaccine design. We have recently categorized 2 new major sub-populations of memory symptomatic and asymptomatic CD8+ T cells based on their phenotype, protective vs. pathogenic function, and anatomical locations. In this report we are discussing a new direction in developing T cell-based human herpes vaccines and immunotherapeutics based on the emerging new concept of ?symptomatic and asymptomatic memory CD8+ T cells.?