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10.4161/hv.27762

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suck abstract from ncbi


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pmid24499824
      Hum+Vaccin+Immunother 2014 ; 10 (4 ): 945-63
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  • Asymptomatic memory CD8+ T cells: from development and regulation to consideration for human vaccines and immunotherapeutics #MMPMID24499824
  • Khan AA ; Srivastava R ; Lopes PP ; Wang C ; Pham TT ; Cochrane J ; Thai NT ; Gutierrez L ; Benmohamed L
  • Hum Vaccin Immunother 2014[]; 10 (4 ): 945-63 PMID24499824 show ga
  • Generation and maintenance of high quantity and quality memory CD8(+) T cells determine the level of protection from viral, bacterial, and parasitic re-infections, and hence constitutes a primary goal for T cell epitope-based human vaccines and immunotherapeutics. Phenotypically and functionally characterizing memory CD8(+) T cells that provide protection against herpes simplex virus type 1 and type 2 (HSV-1 and HSV-2) infections, which cause blinding ocular herpes, genital herpes, and oro-facial herpes, is critical for better vaccine design. We have recently categorized 2 new major sub-populations of memory symptomatic and asymptomatic CD8(+) T cells based on their phenotype, protective vs. pathogenic function, and anatomical locations. In this report we are discussing a new direction in developing T cell-based human herpes vaccines and immunotherapeutics based on the emerging new concept of "symptomatic and asymptomatic memory CD8(+) T cells."
  • |CD8-Positive T-Lymphocytes/*immunology [MESH]
  • |Herpesvirus Vaccines/*immunology [MESH]
  • |Humans [MESH]
  • |Immunologic Memory [MESH]
  • |Immunotherapy/*methods [MESH]


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