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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Hum+Vaccin+Immunother
2014 ; 10
(4
): 945-63
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
Asymptomatic memory CD8+ T cells: from development and regulation to
consideration for human vaccines and immunotherapeutics
#MMPMID24499824
Khan AA
; Srivastava R
; Lopes PP
; Wang C
; Pham TT
; Cochrane J
; Thai NT
; Gutierrez L
; Benmohamed L
Hum Vaccin Immunother
2014[]; 10
(4
): 945-63
PMID24499824
show ga
Generation and maintenance of high quantity and quality memory CD8(+) T cells
determine the level of protection from viral, bacterial, and parasitic
re-infections, and hence constitutes a primary goal for T cell epitope-based
human vaccines and immunotherapeutics. Phenotypically and functionally
characterizing memory CD8(+) T cells that provide protection against herpes
simplex virus type 1 and type 2 (HSV-1 and HSV-2) infections, which cause
blinding ocular herpes, genital herpes, and oro-facial herpes, is critical for
better vaccine design. We have recently categorized 2 new major sub-populations
of memory symptomatic and asymptomatic CD8(+) T cells based on their phenotype,
protective vs. pathogenic function, and anatomical locations. In this report we
are discussing a new direction in developing T cell-based human herpes vaccines
and immunotherapeutics based on the emerging new concept of "symptomatic and
asymptomatic memory CD8(+) T cells."