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10.4161/hv.27380 http://scihub22266oqcxt.onion/10.4161/hv.27380 C4896532!4896532!24335570     free     free     free Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Hum+Vaccin+Immunother 2014 ; 10 (4): 896-910 Nephropedia Template TP {{tp|p=24335570|t=2014. Immunotherapeutic approaches to treat multiple myeloma |pdf=|usr=}}{{24335570}} gab.com Text Immunotherapeutic approaches to treat multiple myeloma JO: Hum Vaccin Immunother http://www.kidney.de/pget.php?&tw=1&pmid=24335570 #FOAvip Cellular immunotherapy can be an effective adjuvant treatment for multiple myeloma (MM), as demonstrated by induction of durable remissions after allogeneic stem cell transplantation. However, anti-myeloma immunity is often hampered by suppressive mechanisms in the tumor micro-environment resulting in relapse or disease progression. To overcome this immunosuppression, new cellular immunotherapies have been developed, based on the important effector cells in anti-myeloma immunity, namely T cells and natural killer cells. These effectors can be modulated to improve their functionality, activated by dendritic cell vaccines, or combined with immune stimulating antibodies or immunomodulatory drugs to enhance their efficacy. In this review, we discuss promising pre-clinical and clinical data in the field of cellular immunotherapy in MM. In addition, we address the potential of combining these strategies with other therapies to maximize clinical effects without increasing toxicity. The reviewed therapies might pave the way to effective personalized treatments for MM patients. Twit Text FOAVip Immunotherapeutic approaches to treat multiple myeloma ????Hum Vaccin Immunother http://www.kidney.de/pget.php?&tw=1&pmid=24335570 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24335570 #FOAvip English Wikipedia <ref>{{Cite pmid|24335570}}</ref> Immunotherapeutic approaches to treat multiple myeloma #MMPMID24335570 Roeven MW; Hobo W; Schaap N; Dolstra H Hum Vaccin Immunother 2014[Apr]; 10 (4): 896-910 PMID24335570show ga Cellular immunotherapy can be an effective adjuvant treatment for multiple myeloma (MM), as demonstrated by induction of durable remissions after allogeneic stem cell transplantation. However, anti-myeloma immunity is often hampered by suppressive mechanisms in the tumor micro-environment resulting in relapse or disease progression. To overcome this immunosuppression, new cellular immunotherapies have been developed, based on the important effector cells in anti-myeloma immunity, namely T cells and natural killer cells. These effectors can be modulated to improve their functionality, activated by dendritic cell vaccines, or combined with immune stimulating antibodies or immunomodulatory drugs to enhance their efficacy. In this review, we discuss promising pre-clinical and clinical data in the field of cellular immunotherapy in MM. In addition, we address the potential of combining these strategies with other therapies to maximize clinical effects without increasing toxicity. The reviewed therapies might pave the way to effective personalized treatments for MM patients. äImmunotherapeutic approaches to treat multiple myeloma (epmc).pdf DeepDyve Pubget Overpricing