A TGF-? pathway associated with cancer cachexia #MMPMID26540384
Guttridge DC
Nat Med 2015[Nov]; 21 (11): 1248-9 PMID26540384show ga
Cancer cachexia leads to involuntary weight loss resulting from the atrophy of skeletal muscle and adipose tissues. Now, in metastatic mouse models of cancer, investigators reveal a cross talk pathway between bone and muscle that provides a new understanding of wasting in advanced cancers.