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10.1038/srep27479 http://scihub22266oqcxt.onion/10.1038/srep27479 C4895339!4895339 !27270362     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=27270362 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\27270362 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Sci+Rep 2016 ; 6 (ä): 27479 Nephropedia Template TP {{tp|p=27270362 |t=2016. Significant decrease in peripheral regulatory B cells is an immunopathogenic feature of dermatomyositis |pdf=|usr=}}{{27270362 }} gab.com Text Significant decrease in peripheral regulatory B cells is an immunopathogenic feature of dermatomyositis JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=27270362 #FOAvip Regulatory B cells (Bregs) are critical in maintaining self-tolerance. Their role in dermatomyositis (DM), an autoimmune disease characterized by inappropriate regulation of hyperactivated B and T cells, has not been clearly defined. In the current study, we performed flow cytometry analysis of studied CD19(+) CD24(high)CD38(high) Breg subpopulations in blood samples from 30 patients with DM, 37 diseased controls and 23 healthy controls. A significant decrease was observed in the frequency of Bregs in DM patients compared to that in diseased controls (p?<?0.0001) and in healthy controls (p?<?0.0001). And the prevalence of Bregs deficiency (defined as Bregs/B cells?<?0.50% in this study) in DM patients went as high as 73.3%. Furthermore, DM patients with positive myositis specific autoantibody often had lower Bregs levels than negative patients (p?=?0.036), and lower level of Bregs was also found in DM patients with interstitial lung disease than in DM patients without (p?=?0.041). In a follow-up study, seven DM patients were considered to be in remission stage, and their Breg levels were found to have significantly increased after treatment (p?=?0.022). Our research revealed that Breg deficiency is an immunopathogenic feature of DM and provided insights into the design of new immunotherapy target for DM clinical interventions. Twit Text FOAVip Significant decrease in peripheral regulatory B cells is an immunopathogenic feature of dermatomyositis ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=27270362 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27270362 #FOAvip English Wikipedia <ref>{{Cite pmid|27270362 }}</ref> Significant decrease in peripheral regulatory B cells is an immunopathogenic feature of dermatomyositis #MMPMID27270362 Li W ; Tian X ; Lu X ; Peng Q ; Shu X ; Yang H ; Li Y ; Wang Y ; Zhang X ; Liu Q ; Wang G Sci Rep 2016[Jun]; 6 (ä): 27479 PMID27270362 show ga Regulatory B cells (Bregs) are critical in maintaining self-tolerance. Their role in dermatomyositis (DM), an autoimmune disease characterized by inappropriate regulation of hyperactivated B and T cells, has not been clearly defined. In the current study, we performed flow cytometry analysis of studied CD19(+) CD24(high)CD38(high) Breg subpopulations in blood samples from 30 patients with DM, 37 diseased controls and 23 healthy controls. A significant decrease was observed in the frequency of Bregs in DM patients compared to that in diseased controls (p? |Antigens, CD/immunology [MESH] |B-Lymphocytes, Regulatory/*immunology [MESH] |Case-Control Studies [MESH] |Cytokines/blood [MESH] |Dermatomyositis/*immunology [MESH] |Female [MESH] |Humans [MESH] |Immunophenotyping [MESH]Significant decrease in peripheral regulatory B cells is an immunopath(epmc).pdf DeepDyve Pubget Overpricing