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10.1038/ncomms11724 http://scihub22266oqcxt.onion/10.1038/ncomms11724 C4894959!4894959!27222343     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Commun 2016 ; 7 (ä): ä Nephropedia Template TP {{tp|p=27222343|t=2016. NFATc1 supports imiquimod-induced skin inflammation by suppressing IL-10 synthesis in B cells |pdf=|usr=}}{{27222343}} gab.com Text NFATc1 supports imiquimod-induced skin inflammation by suppressing IL-10 synthesis in B cells JO: Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=27222343 #FOAvip Epicutaneous application of Aldara cream containing the TLR7 agonist imiquimod (IMQ) to mice induces skin inflammation that exhibits many aspects of psoriasis, an inflammatory human skin disease. Here we show that mice depleted of B cells or bearing interleukin (IL)-10-deficient B cells show a fulminant inflammation upon IMQ exposure, whereas ablation of NFATc1 in B cells results in a suppression of Aldara-induced inflammation. In vitro, IMQ induces the proliferation and IL-10 expression by B cells that is blocked by BCR signals inducing NFATc1. By binding to HDAC1, a transcriptional repressor, and to an intronic site of the Il10 gene, NFATc1 suppresses IL-10 expression that dampens the production of tumour necrosis factor-? and IL-17 by T cells. These data indicate a close link between NFATc1 and IL-10 expression in B cells and suggest NFATc1 and, in particular, its inducible short isoform, NFATc1/?A, as a potential target to treat human psoriasis. Twit Text FOAVip NFATc1 supports imiquimod-induced skin inflammation by suppressing IL-10 synthesis in B cells ????Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=27222343 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27222343 #FOAvip English Wikipedia <ref>{{Cite pmid|27222343}}</ref> NFATc1 supports imiquimod-induced skin inflammation by suppressing IL-10 synthesis in B cells #MMPMID27222343 Alrefai H; Muhammad K; Rudolf R; Pham DAT; Klein-Hessling S; Patra AK; Avots A; Bukur V; Sahin U; Tenzer S; Goebeler M; Kerstan A; Serfling E Nat Commun 2016[]; 7 (ä): ä PMID27222343show ga Epicutaneous application of Aldara cream containing the TLR7 agonist imiquimod (IMQ) to mice induces skin inflammation that exhibits many aspects of psoriasis, an inflammatory human skin disease. Here we show that mice depleted of B cells or bearing interleukin (IL)-10-deficient B cells show a fulminant inflammation upon IMQ exposure, whereas ablation of NFATc1 in B cells results in a suppression of Aldara-induced inflammation. In vitro, IMQ induces the proliferation and IL-10 expression by B cells that is blocked by BCR signals inducing NFATc1. By binding to HDAC1, a transcriptional repressor, and to an intronic site of the Il10 gene, NFATc1 suppresses IL-10 expression that dampens the production of tumour necrosis factor-? and IL-17 by T cells. These data indicate a close link between NFATc1 and IL-10 expression in B cells and suggest NFATc1 and, in particular, its inducible short isoform, NFATc1/?A, as a potential target to treat human psoriasis. äNFATc1 supports imiquimod-induced skin inflammation by suppressing IL-(epmc).pdf DeepDyve Pubget Overpricing