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10.1007/s00018-016-2175-4 http://scihub22266oqcxt.onion/10.1007/s00018-016-2175-4 C4894934!4894934!26979166     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cell+Mol+Life+Sci 2016 ; 73 (ä): 2511-30 Nephropedia Template TP {{tp|p=26979166|t=2016. Modulatory effects of ?7 nAChRs on the immune system and its relevance for CNS disorders |pdf=|usr=}}{{26979166}} gab.com Text Modulatory effects of 7 nAChRs on the immune system and its relevance for CNS disorders JO: Cell Mol Life Sci http://www.kidney.de/pget.php?&tw=1&pmid=26979166 #FOAvip The clinical development of selective alpha-7 nicotinic acetylcholine receptor (?7 nAChR) agonists has hitherto been focused on disorders characterized by cognitive deficits (e.g., Alzheimer?s disease, schizophrenia). However, ?7 nAChRs are also widely expressed by cells of the immune system and by cells with a secondary role in pathogen defense. Activation of ?7 nAChRs leads to an anti-inflammatory effect. Since sterile inflammation is a frequently observed phenomenon in both psychiatric disorders (e.g., schizophrenia, melancholic and bipolar depression) and neurological disorders (e.g., Alzheimer?s disease, Parkinson?s disease, and multiple sclerosis), ?7 nAChR agonists might show beneficial effects in these central nervous system disorders. In the current review, we summarize information on receptor expression, the intracellular signaling pathways they modulate and reasons for receptor dysfunction. Information from tobacco smoking, vagus nerve stimulation, and cholinesterase inhibition is used to evaluate the therapeutic potential of selective ?7 nAChR agonists in these inflammation-related disorders. Twit Text FOAVip Modulatory effects of 7 nAChRs on the immune system and its relevance for CNS disorders ????Cell Mol Life Sci http://www.kidney.de/pget.php?&tw=1&pmid=26979166 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26979166 #FOAvip English Wikipedia <ref>{{Cite pmid|26979166}}</ref> Modulatory effects of ?7 nAChRs on the immune system and its relevance for CNS disorders #MMPMID26979166 Kalkman HO; Feuerbach D Cell Mol Life Sci 2016[]; 73 (ä): 2511-30 PMID26979166show ga The clinical development of selective alpha-7 nicotinic acetylcholine receptor (?7 nAChR) agonists has hitherto been focused on disorders characterized by cognitive deficits (e.g., Alzheimer?s disease, schizophrenia). However, ?7 nAChRs are also widely expressed by cells of the immune system and by cells with a secondary role in pathogen defense. Activation of ?7 nAChRs leads to an anti-inflammatory effect. Since sterile inflammation is a frequently observed phenomenon in both psychiatric disorders (e.g., schizophrenia, melancholic and bipolar depression) and neurological disorders (e.g., Alzheimer?s disease, Parkinson?s disease, and multiple sclerosis), ?7 nAChR agonists might show beneficial effects in these central nervous system disorders. In the current review, we summarize information on receptor expression, the intracellular signaling pathways they modulate and reasons for receptor dysfunction. Information from tobacco smoking, vagus nerve stimulation, and cholinesterase inhibition is used to evaluate the therapeutic potential of selective ?7 nAChR agonists in these inflammation-related disorders. äModulatory effects of ?7 nAChRs on the immune system and its relevance(epmc).pdf DeepDyve Pubget Overpricing