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10.1097/PPO.0000000000000055 http://scihub22266oqcxt.onion/10.1097/PPO.0000000000000055 C4894310!4894310!25098288     free     free     free Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cancer+J 2014 ; 20 (4): 272-80 Nephropedia Template TP {{tp|p=25098288|t=2014. Subverting the B7-H1/PD-1 Pathway in Advanced Melanoma and Kidney Cancer |pdf=|usr=}}{{25098288}} gab.com Text Subverting the B7-H1/PD-1 Pathway in Advanced Melanoma and Kidney Cancer JO: Cancer J http://www.kidney.de/pget.php?&tw=1&pmid=25098288 #FOAvip Ligands for inhibitory immune receptors on T cells may be constitutively expressed on tumor cells or host cells in tumor microenvironment as a consequence of adaptive immunity. Programmed death 1 (PD-1) is 1 such receptor on T cells, which functions as a negative regulator of T cell activity. Tumors that up-regulate programmed death ligand 1 (PD-L1) (B7-H1) may abrogate the host?s effector T cell antitumor response. Higher tumoral PD-L1 expression has been linked with inferior clinical outcomes. Multiple cancers including renal cell cancers (RCCs) and melanomas have relatively high levels of PD-L1 on the cell surface. Early evaluations of antibodies that block the interaction of PD-1 and PD-L1 have shown efficacy and a favorable tolerability profile with notable inflammatory toxicities that are generally manageable. Upward of 30% of RCC patients and 50% of melanoma patients achieve objective responses. Durable responses can occur, even in some patients who have discontinued treatment. The developing investigation of PD-1/PD-L1 pathway?blocking agents in RCC and melanoma will likely alter our approaches to the treatment of these 2 deadly diseases. Twit Text FOAVip Subverting the B7-H1/PD-1 Pathway in Advanced Melanoma and Kidney Cancer ????Cancer J http://www.kidney.de/pget.php?&tw=1&pmid=25098288 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25098288 #FOAvip English Wikipedia <ref>{{Cite pmid|25098288}}</ref> Subverting the B7-H1/PD-1 Pathway in Advanced Melanoma and Kidney Cancer #MMPMID25098288 Harshman LC; Choueiri TK; Drake C; Hodi FS Cancer J 2014[Jul]; 20 (4): 272-80 PMID25098288show ga Ligands for inhibitory immune receptors on T cells may be constitutively expressed on tumor cells or host cells in tumor microenvironment as a consequence of adaptive immunity. Programmed death 1 (PD-1) is 1 such receptor on T cells, which functions as a negative regulator of T cell activity. Tumors that up-regulate programmed death ligand 1 (PD-L1) (B7-H1) may abrogate the host?s effector T cell antitumor response. Higher tumoral PD-L1 expression has been linked with inferior clinical outcomes. Multiple cancers including renal cell cancers (RCCs) and melanomas have relatively high levels of PD-L1 on the cell surface. Early evaluations of antibodies that block the interaction of PD-1 and PD-L1 have shown efficacy and a favorable tolerability profile with notable inflammatory toxicities that are generally manageable. Upward of 30% of RCC patients and 50% of melanoma patients achieve objective responses. Durable responses can occur, even in some patients who have discontinued treatment. The developing investigation of PD-1/PD-L1 pathway?blocking agents in RCC and melanoma will likely alter our approaches to the treatment of these 2 deadly diseases. äSubverting the B7-H1/PD-1 Pathway in Advanced Melanoma and Kidney Canc(epmc).pdf DeepDyve Pubget Overpricing